戒烟对小气道功能的影响  

Effects of Quitting Smoking on Small Airway Function

作　　者：岳秀 杨玉东 樊建勇 

机构地区：[1]西安市兵器工业521医院呼吸内科,西安710065

出　　处：《实用临床医学（江西）》2015年第2期11-13,共3页Practical Clinical Medicine

摘　　要：目的探讨长期吸烟者不同戒烟时间对小气道功能的影响。方法选择有小气道功能病变的长期吸烟男性患者23例为戒烟组,非吸烟健康男性28例为对照组,分别测定戒烟组戒烟前及戒烟后3、6、9及12个月及对照组(入选后12个月内)的小气道功能[最大呼气中段流量(MMEF)、用力呼出25%肺活量时呼气流量(FEF25%)、用力呼出50%肺活量时呼气流量(FEF50%)、用力呼出75%肺活量时呼气流量(FEF75%)],比较戒烟各时间段小气道功能的变化。结果戒烟组戒烟后3个月各项指标与戒烟前比较差异均无统计学意义(均P>0.05);戒烟后6个月MMEF、FEF25%、FEF50%较戒烟前均有所提高(均P<0.05);戒烟后9、12个月MMEF、FEF25%、FEF50%及FEF75%较戒烟前均明显提高(均P<0.01);戒烟组戒烟后12个月的FEF25%、FEF50%与对照组比较差异均无统计学意义(均P>0.05)。结论无症状吸烟者戒烟后6个月方能改善小气道功能。戒烟后12个月FEF25%与FEF50%可恢复至正常。Objective To investigate the effects of different durations of smoking cessation on small airway function in long-term smokers.Methods The maximal midexpiratory flow (MMEF) and the forced expiratory flow at 50% and 75% of expired volume (FEF25%,FEF50% and FEF75%,respectively)were measured in 23 long-term male smokers with small airway disease (smoking cessation group)and 28 non-smoking healthy men (control group)before and 3,6,9 and 12 months after quitting smoking.The changes in small airway function were compared be-tween the two groups.Results No significant changes in all the parameters measured were found 3 months after quitting smoking (P >0.05).However,the MMEF,FEF25% and FEF50% were increased 6 months after quitting smoking (P < 0.05 ),the MMEF,FEF25%,FEF50% and FEF75% were obviously improved 9 and 12 months after quitting smoking (P < 0.01).There were no significant differences in FEF25% and FEF50% between the two groups 12 months after quitting smoking (P >0.05).Conclusion The small airway function can be improved 6 months after quitting smoking,and both FEF25% and FEF50% can be restored to normal 12 months af-ter quitting smoking in asymptomatic smokers.

关 键 词：戒烟 小气道功能 小气道病变 无症状吸烟者 

分 类 号：R562[医药卫生—呼吸系统]