中药穴位敷贴对支气管哮喘急性发作期患者嗜酸性粒细胞计数、IgE及呼出一氧化氮水平的影响  

Impact of Chinese Herbs Acupoint Application in Patients with Bronchial Asthma in Acute Exacerbation on Eosinophil Count,Immunoglobulin E and Nitric Oxide

作　　者：王鹏[1] 杨文林[1] 李星晶[1] 王丽华[1] 

机构地区：[1]上海市第一人民医院宝山分院呼吸内科,上海200940

出　　处：《中国中医药科技》2015年第1期9-11,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察中药穴位敷贴治疗支气管哮喘急性发作期的疗效及其对嗜酸性粒细胞计数(EOS)、免疫球蛋白E(Ig E)和呼出一氧化氮(Fe NO)水平的影响。方法:选择支气管哮喘急性发作期的患者90例,随机分为观察组和对照组,每组45例。对照组予以常规治疗,观察组在对照组的基础上予以中药穴位敷贴治疗。1个疗程后观察两组的疗效,治疗前后肺活量(VC)、用力肺活量(FVC)、1秒钟用力呼气容积/用力肺活量(FEV1/FVC)、EOS、Ig E和Fe NO水平的变化。结果:观察组的总有效率为97.78%,优于对照组的82.22%(P<0.05)。治疗后两组的VC、FVC和FEV1/FVC水平较治疗前明显增高(P<0.01),观察组作用更为明显(P<0.05或<0.01);而两组的EOS、Ig E和Fe NO水平较治疗前明显降低(P<0.05),观察组的作用更为明显(P<0.01)。结论:中药穴位敷贴联合西医治疗支气管哮喘急性发作的疗效确切,可降低机体免疫反应,减轻气道炎症反应。Objective： To observe the efficacy of Chinese herbs acupoint application in patients with bronchial asthma in acute exacerbation and its impact on eosinophil count（ EOS）,immunoglobulin E（ Ig E）,and fractional exhaled nitric oxide（ Fe NO）. Methods： 90 patients with bronchial asthma in acute exacerbation were randomly divided into observation group and control group,each group had 45 cases. The control group received conventional treatment,observation group was gaven acupoint application on the basis of the control group. The efficacy in two groups,vital capacity（ VC）,forced vital capacity（ FVC）,forced expiratory volume in one second /forced vital capacity（ FEV1/ FVC）,EOS,Fe NO and Ig E were observed after or before treatment. Results： The total effective rate was 97. 78% in observation group that was better than in control group（ 82. 22%）（ P〈0. 05）. After treatment,the levels of VC,FVC and FEV1/ FVC in two groups were significantly higher than those before treatment（ P〈0. 01）,the elevated levels in observation group were significantly more obvious（ P〈0. 05 or 〈0. 01）; while the levels of EOS,Ig E and Fe NO in two groups were significantly lower than those before treatment（ P〈0. 05）,the decreasing in observation group were more obvious（ P〈0. 01）. Conclusion： The efficacy of acupoint application combined with western medicine can effectively treat bronchial asthma in aucte exacerbation by reducing immune response and airway inflammation.

关 键 词：哮喘 急性病 穴位敷贴 嗜酸性粒细胞 免疫球蛋白E 一氧化氮 

分 类 号：R246.1[医药卫生—针灸推拿学]