首发精神分裂症患者糖脂代谢异常及其与白细胞介素1的关系  

Study of glucose and lipid metabolic disorders in first-episode patients with schizophrenia and their relations with interleukin-1

作　　者：卢玮聪[1] 梁卉薇[1] 吴逢春[1] 

机构地区：[1]广州市惠爱医院(广州市脑科医院)情感障碍科,510370

出　　处：《神经疾病与精神卫生》2015年第1期44-47,共4页Journal of Neuroscience and Mental Health

基　　金：广州市医药卫生科技项目（20121A011090）

摘　　要：目的 比较首发精神分裂症患者糖脂代谢与健康人群的差异,探讨其与白细胞介素-1（IL-1β）及白介素-1受体拮抗剂（IL-1R）的关系.方法 入组符合ICD-10精神分裂症诊断标准的首发患者47例（病例组）及健康对照32人（对照组）,收集一般人口学资料,测定空腹血糖、餐后血糖等代谢指标,血清IL-1β及IL-1 Rα水平,比较两组的差异;以是否患糖调节异常（IGR）分组,分析组间的IL-1β及IL-1 Rα水平差异.结果 两组的空腹血糖水平差异无统计学意义（P＞0.05）,但病例组餐后血糖较高（P＜0.01）.病例组血清IL-1β水平较对照组高（P＜0.01）.病例组糖调节异常（IGR）者12例,而对照组为0例;IL-1β及IL-1Rα水平在IGR患者、无IGR的患者及对照组间差异均有统计学意义（P＜0.01）.结论 首发的精神分裂症患者已存在糖代谢异常,该异常可能和血清IL-1β及IL-1Rα水平有关.Objective To compare glucose and lipid levels of first--episode schizophrenia patients with health control and to explore their relationship with interleukin-lbeta（IL-16） and interleukin-1 receptor antagonist α（IL-1Rα）. Methods Forty-seven patients diagnosed with schizophrenia with the Tenth Revision of the International Statistical Classification of Diseases and Related Health Problems （ICD-10） and 32 health controls were enrolled. Demographic data was collected. Compared the difference between two groups in the fasting plasma glucose（FPG）, post--prandial blood glucose（PBG）of 2 hours, plasma concentration of IL-16 and IL-1Rα. The concentration of IL-1β and IL-1Rα were also compared between groups with and without impaired glucose regulation（IGR）. Results There was no significant difference in FPG between the two groups （P 〉 0.05）. But PBG in patients group was higher （P 〈0.01）. The level of IL-1β in patients was higher than the controls （P 〈 0.01）. There were 12 people with IGR in patients group and none in control group. The concentrations of both IL-1β and IL -1Rα were significantly different between patients with IGR, patients without IGR and control group （P 〈 0.01）. Conclusions There are significant glucose metabolic disorders in first first-episode schizophrenia patients and they may have relationship with the plasma concentration of IL-1β and IL- 1Rα.

关 键 词：精神分裂症 糖调节异常 白介素-1Β 白介素-1受体拮抗剂α 

分 类 号：R971.4[医药卫生—药品]