血清胆红素、尿酸、低密度脂蛋白与冠心病的关系  

Clinical study on correlation of bilirubin,uric acid and low density lipoprotein with coronary heart disease

作　　者：谢则金[1] 王厚照[1] 张福军[1] 

机构地区：[1]解放军第174医院(厦门大学附属成功医院)检验科,福建厦门361003

出　　处：《临床军医杂志》2015年第2期119-120,153,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨血清胆红素、尿酸(UA)、低密度脂蛋白(LDL-C)在冠心病(CHD)发生发展中的意义。方法选择我院心内科进行冠状动脉造影检查确诊的32例冠心病患者作为观察组,32例健康体检成人作为对照组。测定血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、UA、LDL-C指标并分析与冠心病的关系。结果与健康对照组相比,CHD组UA、LDL-C水平均显著升高(P<0.01),而TBIL、DBIL水平均显著下降(P<0.01),IBIL虽有下降但差异无统计学意义(P>0.05)。结论胆红素、UA、LDL-C可能相互影响参与冠心病的发生与发展,早期干预有可能预防心血管事件的发生。Objective To investigate the relationship ofserum bilirubin（ BIL）,uric acid（ UA） and low density lipoprotein-C（ LDL-C）with the occurrence and the development of coronary heart disease（ CHD）. Methods A total of 32 CHD patients（ CHD group）and 32 healthy controls（ control group） were enrolled. Their serum levels of total BIL（ TBIL）,direct BIL（ DBIL）,indirect BIL（ IBIL）,UA and LDL-C were measured and compared. Results In the CHD group,the levels of UA and LDL-C were significantly elevated,while that of TBIL and DBIL were markedly declined（ P〈0. 01）. There was no significant difference in IBIL between the two groups（ P〉0. 05）. Conclusion With some influence on CHD,BIL,UA and LDL-C may take part in the pathogenesis of the disease,and therefore the early intervention in them possibly helps to prevent its occurrence and development.

关 键 词：冠心病 胆红素 尿酸 低密度脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]