血清标志物对复发性流产的临床诊断价值  

Clinical significance of co-measurement of two different serum antibodies in women with recurrent spontaneous abortion

作　　者：庞苗苗[1] 李娜 韩华[1] 逯蕾[1] 刘征丽[1] 

机构地区：[1]武警陕西总队医院妇产科,陕西西安710054 [2]陕西省妇幼保健院,陕西西安710003

出　　处：《临床军医杂志》2015年第2期168-170,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨血清抗心磷脂抗体(ACA)、抗β2-糖蛋白I抗体(AGA)联合检测对复发性流产(RSA)的临床诊断价值。方法选取63例RSA患者为实验组,60例正常经产妇为对照组,检测两组受检者血清ACA和AGA水平。结果实验组的ACA阳性率为25.06%,对照组为8.33%,差异有显著统计学意义(P<0.01);实验组的AGA阳性率为20.63%,对照组为5%,差异有显著统计学意义(P<0.01)。在确诊的50例抗磷脂抗体综合征(APS)患者中,ACA和AGA联合检测的阳性预测值为67.5%,明显高于其他组。结论 (1)ACA和AGA与RSA有关。(2)ACA和AGA联合检测可以提高RSA患者APS的检出率,对于临床诊断有重要意义。Objective To investigate the clinical value of co-measurement of anticardiolipin antibody（ ACA） and antibeta 2-glycoprotein I antibody（ AGA） in women with recurrent spontaneous abortion（ RSA）. Methods Levels of ACA and AGA were detected in 63 women with RSA（ trial group） and 60 normal multigravidas（ control group）. Results Positive rates of ACA and AGA were 25. 06% vs 8. 3% and 20. 63% vs 5%（ trial group vs control group）,respectively. And the differences between the two groups were significant（ P〈0. 01）. In the 50 women definitely diagnosed with antiphosphlipid syndrome（ APS）,the combined positive rate of ACA and AGA was 67. 5%. Conclusion（ 1） ACA and AGA were related to RSA.（ 2） The co-measurement of ACA and AGA may increase the positive rate in screening APS in RSA patients.

关 键 词：复发性流产 抗心磷脂抗体 抗Β2-糖蛋白I抗体 

分 类 号：R714.21[医药卫生—妇产科学]