磷酸川芎嗪微乳凝胶化及其透皮性质研究  

Study on the gelatinization of ligustrazine phosphate microemulsion and its transdermal characters

作　　者：陈凯[1] 张金安[1] 崔颖[2,3] 胡霞[1] 郭均平[1] 

机构地区：[1]武警湖北总队医院药剂科,湖北武汉430064 [2]武警后勤学院药物化学教研室,天津300309 [3]天津市职业危害与防制重点实验室,天津300309

出　　处：《武警后勤学院学报（医学版）》2015年第1期18-20,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】研究不同增稠剂对磷酸川芎嗪微乳增稠效果以及微乳凝胶体外透皮性质的影响。【方法】通过磁力搅拌法考察不同高分子辅料增稠的效果,并采用立式Franz扩散池法考察不同浓度Aerosil 200对磷酸川芎嗪微乳体外渗透曲线及参数影响。【结果】在采用的增稠剂中,仅Aerosil 200能够增加磷酸川芎嗪微乳的稠度,同时不改变其微乳性质,随着Aerosil 200浓度升高,其微乳凝胶的黏度分别升高为62.19,87.35,116.47,127.81和153.45 Pas;但是随Aerosil 200浓度升高(4%,5%,6%),药物透皮速率分别下降为95.69,77.76,59.48μg·(cm2·h)-1。【结论】含有5%Aerosil 200的磷酸川芎嗪微乳具有澄清透明的凝胶结构,同时具有适当的黏度和透皮速率。【Objective】To study the effects of different thickening agents on ligustrazine phosphate microemulsion and in vitro transdermal characters of the microemulsion gel.【Method】The effects of different macromolecular thickening agents on microemulsion were studied with magnetic stirring method, and the transdermal curves and parameters of ligustrazine phosphate microemulsion by Aerosil 200 in different concentrations were investigated with FRANZ diffusion method.【Result】The transparent gel was prepared only with the application of Aerosil 200 in ligustrazine phosphate microemulsion without destruction of microemulsion structure. The viscosity increased to 62.19,87.35,116.47,127.81,153.45 Pas at Aerosil 200 concentrations of 3%,4%,5%,6%,7%,while the transdermal flux decreased to 95.69,77.76,59.48 μg·（cm2·h）- 1with the increase of Aerosil 200 concentration from 4 to 6%.【Conclusion】In general consideration of transparent gel structure,suitable viscocity and transdermal flux, ligustrazine phosphate microemulsion with 5% Aerosil 200 was the optimal choice.

关 键 词：磷酸川芎嗪 微乳 凝胶 透皮速率 

分 类 号：R94[医药卫生—药剂学]