111例稽留流产胎儿绒毛染色体核型分析  

Karyotyping analysis on fetal chorionic villi in 111 cases with missed abortion

作　　者：陈瑞红[1] 刘玉玲[1] 

机构地区：[1]郑州大学第二附属医院妇产科,河南郑州450014

出　　处：《中国妇幼保健》2015年第8期1211-1212,共2页Maternal and Child Health Care of China

基　　金：全国妇女发展基金会伊爱基金资助项目;河南省人口和计划生育科学技术研究项目

摘　　要：目的:对111例稽留流产患者胎儿绒毛染色体进行分析,探寻流产原因。方法:对111例稽留流产患者取无菌绒毛进行细胞培养和染色体制备及核型分析。结果:111例稽留流产绒毛染色体中,染色体核型正常28例(25.23%),染色体核型异常83例(74.77%)。异常核型中,性染色单体2例(2.41%),三体19例(22.89%),嵌合体51例(61.45%),复合三体1例(1.20%),三倍体7例(8.43%),四倍体3例(3.61%)。结论:胚胎染色体异常是稽留流产的主要原因,绒毛染色体核型分析有利于查明胚胎停育的原因,为遗传咨询和优生优育指导提供依据。Objective： To analyze chorionic villi chromosome in 111 cases with missed abortion,explore the reasons of abortion.Methods： Cell culture,chromosomal preparation and karyotyping analysis were performed based on sterile villous specimens from 111 cases with missed abortion. Results： Among 111 cases,11 cases（ 25. 23%） was found with normal karyotype,83 cases（ 74. 77%） were found with abnormal karyotypes. Among the cases with abnormal karyotypes,2 cases（ 2. 41%） were found with sexual chromatid,19 cases（ 22. 89%） were found with trisomy,51 cases（ 61. 45%） were found with mosaics,1 case（ 1. 20%） was found with complex trisomy,7cases（ 8. 43%） were found with triploid,3 cases（ 3. 61%） were found with tetraploid. Conclusion： Embryo chromosomal abnormalities are the important reasons of missed abortion,karyotyping analysis of chorionic villi is beneficial for identifying the causes of embryo development arrest,and it can provide a reliable evidence for genetic consultation and guidance of aristogenesis.

关 键 词：稽留流产 绒毛 染色体核型 胎儿 

分 类 号：R714.5[医药卫生—妇产科学]