中国不同胎龄新生儿出生体重曲线研制  

Chinese neonatal birth weight curve for different gestational age

作　　者：朱丽[1] 张蓉[1] 张淑莲[1] 石文静[1] 严卫丽[2] 王晓莉[3] 吕勤[4] 刘玲 周勤[6] 邱全芳 李晓莺[8] 何海英 汪吉梅[10] 黎瑞春[11] 陆嘉荣 尹兆青 苏萍[14] 林新祝 郭芳[16] 张慧[17] 李树军[18] 新华 韩彦青[20] 王红云 陈冬梅 李占魁 王慧琴[24] 邱银萍[25] 刘华艳 杨杰[27] 杨晓丽[28] 李明霞[29] 李文静 韩树萍[31] 曹蓓[32] 易彬[33] 张亦慧 陈超[1] 无 

机构地区：[1]复旦大学附属儿科医院新生儿科,上海201102 [2]复旦大学附属儿科医院临床流行病学研究室,上海201102 [3]上海市嘉定区妇幼保健院新生儿科,201821 [4]浙江省宁波市妇女儿童医院新生儿ICU,315012 [5]贵州省妇幼保健院新生儿科,贵阳550003 [6]江苏省无锡市妇幼保健院新生儿科,214002 [7]拉萨市人民医院儿科,850000 [8]山东大学齐鲁儿童医院新生儿科,济南250022 [9]内蒙古自治区包钢集团第三医院新生儿科,包头014010 [10]复旦大学附属妇产科医院新生儿科,上海200090 [11]江西省九江市妇幼保健院新生儿科,332000 [12]新疆维吾尔自治区伊犁州妇幼保健院新生儿科,835000 [13]云南省德宏州医疗集团新生儿科,678400 [14]广西壮族自治区玉林市第一人民医院新生儿科,537000 [15]厦门市妇幼保健院新生儿科,361003 [16]昆明市妇幼保健院新生儿科,650031 [17]四川省江油市人民医院新生儿科,621700 [18]新乡医学院第一医院新生儿科,453000 [19]新疆维吾尔自治区博尔塔拉蒙古自治州人民医院新生儿科,833400 [20]四川省妇幼保健院新生儿科,成都610000 [21]内蒙古自治区妇幼保健院新生儿科,呼和浩特010020 [22]福建省泉州市妇幼保健院新生儿科,362000 [23]陕西省妇幼保健院新生儿科,西安710003 [24]合肥市妇幼保健院新生儿科,230000 [25]宁夏医科大学附属医院新生儿科,银川750004 [26]黑龙江省牡丹江市妇女儿童医院新生儿科,157000 [27]广东省妇幼保健院新生儿科,广州511400 [28]山西省人民医院儿科,太原030021 [29]新疆医科大学第一附院新生儿科,乌鲁木齐830054 [30]北京市妇产医院新生儿科,100006 [31]南京市妇幼保健院新生儿科,210004 [32]湖南省妇幼保健院新生儿科,长沙410008 [33]甘肃省妇幼保健院新生儿科,兰州730000 [34]山东省日照市莒县人民医院新生儿科,276500 [35]中国新生儿协作网

出　　处：《中华儿科杂志》2015年第2期97-103,共7页Chinese Journal of Pediatrics

摘　　要：目的 调查我国新生儿出生体重状况,制定新的新生儿出生体重标准,绘制不同出生胎龄新生儿出生体重曲线.方法 在全国范围内建立新生儿协作网,收集产科出生的新生儿数据.在全国七大区域23个省、市、自治区,共有63家医院设立监测点.研究对象为2011-2014年各监测点出生的单胎活产儿,采用连续收集的方法收集产科出生新生儿的胎龄和出生体重数据.新生儿生后2h内用电子秤进行裸身体重测量,胎龄判断为母亲末次月经、孕早期超声检查和出生后胎龄评分相结合的方法.出生体重曲线拟合方法采用LMSP方法,利用R2.11.1软件中的基于位置、尺度、形状的广义可加模型（GAMLSS） 1.9-4软件包进行曲线绘制和检验.结果 共收集单胎新生儿159 334名,其中男84 447名,女74 907名,平均出生体重（3 232±555）g,其中男性平均体重（3 271±576）g,女性平均出生体重（3 188±528）g.对新生儿出生体重数据的正态分布进行检验,结果提示胎龄和体重数据分布均不符合正态分布,BCT分布拟合度最优.用虫形图检测和拟合模型残差图检验,提示本曲线较好拟合了本研究的数据分布.采用同样的方法分别绘制男性新生儿和女性新生儿出生体重曲线.结论 对我国不同出生胎龄新生儿出生体重参考值进行了更新,使用GAMLSS方法建立新生儿出生体重曲线,分性别制定不同参考曲线,制定的出生体重曲线经统计学检验提示较为准确拟合实际情况.Objective Since 1986,the reference of birth weight for gestational age has not been updated.The aim of this study was to set up Chinese neonatal network to investigate the current situation of birth weight in China,especially preterm birth weight,to develop the new reference for birth weight for gestational age and birth weight curve.Method A nationwide neonatology network was established in China.This survey was carried out in 63 hospitals of 23 provinces,municipalities and autonomous regions.We continuously collected the information of live births in participating hospitals during the study period of 2011-2014.Data describing birth weight and gestational age were collected prospectively.Newborn＇s birth weight was measured by electronic scale within 2 hours after birth when baby was undressed.The evaluation of gestational age was based on the combination of mother＇s last menstrual period,ultrasound in first trimester and gestational age estimation by gestational age scoring system.Statistical analysis：the growth curve was drawn by using LMSP method,which was conducted in GAMLSS 1.9-4 software package in R software 2.11.1.Result A total of 159 334 newborn infants were enrolled in this study.There were 84 447 male and 74 907 female.The mean birth weight was （3 232 ± 555） g,the mean birth weight of male newborn was （3 271 ±576） g,the mean weight of female newborn was （3 188 ±528）g.The test of the variables＇ distribution suggested that the distribution of gestational age and birth weight did not fit the normal distribution,the optimal distribution for them was BCT distribution.The Q-Q plot test and worm plot test suggested that this curve fitted the distribution optimally.The male and female neonatal birth weight curve was developed using the same method.Conclusion Using GAMLSS method to establish nationwide neonatal birth weight curve,and the first time to update the birth weight reference in recent 28 years.

关 键 词：婴儿 新生 出生体重 生长曲线表 参考标准 

分 类 号：R722[医药卫生—儿科]