Copper(I)/Sa BOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with a-nitrodiazoacetates  

手性铜(I)/SaBOX配合物催化cis-1,2-二取代烯烃与α-硝基重氮乙酸酯的高非对映选择性以及高对映选择性环丙烷化反应（英文）

作　　者：冯良文 王鹏 王丽佳 唐勇 

机构地区：[1]The State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences [2]Collaborative Innovation Center of Chemical Science and Engineering

出　　处：《Science Bulletin》2015年第2期210-215,I0002,共7页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(21421091,21432011 and21272250);the Chinese Academy of Sciences

摘　　要：A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitrodiazo acetates has been developed, giving the desired products in up to 97 % yields, up to 〉99/1 dr and up to 98 % ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.利用手性金属铜(I)与边臂修饰的双噁唑啉的配合物作为催化剂,发展了一种催化cis-1,2-二取代烯烃与α-硝基重氮乙酸酯发生高立体选择性环丙烷化反应的新方法.该反应可以获得高达97%的收率、99/1 dr和98%的对映选择性,得到多取代的手性环丙烷.这一方法为合成具有光学活性的环丙烷α-氨基酸以及非天然α-氨基酸衍生物提供了有效途径.

关 键 词：Asymmetric catalysis CYCLOPROPANATION Sidearm BISOXAZOLINE α-Amino acids 

分 类 号：O643.32[理学—物理化学]