高同型半胱氨酸在亚急性联合变性中的诊断价值  

Diagnostic value of hyperhomocysteinaemia in subacute combined degeneration of spinal cord

作　　者：刘慧勤[1] 宋坤 张杰文[1] 姚勇[1] 张健[1] 

机构地区：[1]河南省人民医院,郑州450003 [2]方城县人民医院,河南方城473200

出　　处：《医药论坛杂志》2015年第1期15-17,共3页Journal of Medical Forum

摘　　要：目的探讨高同型半胱氨酸血症(hyperhomocysteinaemia Hhcy)在亚急性联合变性(subacute combined degeneration,SCD)中的诊断意义。方法回顾性分析临床确诊的26例SCD患者及25例健康对照的临床资料、血常规、血清同型半胱氨酸(homocysteine Hcy)、维生素B12、神经电生理检查、MRI检查,并观察其特点,对比SCD组与健康对照组血清Hcy的差异。结果 SCD组的血清Hcy水平明显高于健康对照组,其差异具有统计学意义[(77.83±62.87)μmol/L与(16.19±6.95)μmol/L,t=4.968,P<0.01];维生素B12治疗后SCD患者Hcy明显下降(t=0.394,P=0.001)。结论 Hhcy可作为SCD临床诊断及病情变化的重要生物学指标。Objective To explore the diagnostic value of hyperhomocysteinaemia（Hhcy） in subacute combined degeneration of spinal cord（SCD）. Methods Totally 26 defined SCD patients and 25 healthy controls were included in this ret- rospectively study. The patients underwent routine blood test, blood serum vitamin B12, blood homocysteine（Hcy） , neuro-logical electrophysiology and the magnetic resonance imaging（MRI） of spinal cord,the blood Hcy results of the patients were compared with those of the controls. The levels of blood Hcy before and after vitamin B12 treatment were also compared. Results There was a significant difference between the level of the blood Hcy of the SCD group and that of the controls[ （77.83 ± 62.87 ） μmol/L and （ 16. 19 ± 6. 95 ） μmol/L, t = 4. 968, P 〈 0. 01]; and the level of blood Hcy of three SCD patient was significantly deereaced after the vitamin B12 treatment（ t = 0. 394,P = 0. 001 ）. Conclusion Hhcy provides significant value in the diagnosis of SCD, and also may be an important biological marker to reflect the condition changes of SCD patients.

关 键 词：高同型半胱氨酸血症 亚急性联合变性 同型半胱氨酸 维生素B12 

分 类 号：R591.4[医药卫生—内科学]