原发性高血压患者心外膜脂肪体积与颈动脉粥样硬化的关系  

Association between epicardial fat volume with carotid atherosclerosis in patients with essential hypertension

作　　者：贺燕林[1] 郝宏毅[1] 哈若水[1] 吴金花[1] 马小芳[1] 

机构地区：[1]宁夏自治区人民医院,银川750021

出　　处：《临床心血管病杂志》2015年第2期221-224,共4页Journal of Clinical Cardiology

基　　金：宁夏自然科学基金项目(No:NZ09153)

摘　　要：原发性高血压病是以血压升高为主要临床表现,伴或不伴有多种心血管危险因素的综合征,是多种心脑血管疾病的重要病因和危险因素。心外膜脂肪是心脏周围的内脏脂肪,既是能量储库,也是内分泌器官。近年来研究表明,心外膜脂肪与高血压、冠心病、糖尿病、代谢综合征、心率失常、动脉硬化、各种炎性细胞因子及其基因表达等密切相关[1-4]。Summary We measured epicardial fat volumw （EFV） in 279 patients and analyzed the possible risk factors for carotid atherpsclerosis in patients with essential hypertension （EH）. Percentages of patients＂ mean age, BMI, fasting plasma glucose （FPG） level, uric acid level, β2-microglobulin level, EFV and history of nonalcoholic fatty liver disease, type 2 diabetes mellitus （T2DM） and carotid atherosclerosis were significantly greater in patients with EH than those without （all P〈0.05）. Logistic regression results showed that EFV, age, uric acid level and carotid atherosclerosis were positively correlated with EH. Percentages of patients＂ mean age, FPG level, uric acid level, EFV and history of nonalcoholic fatty liver disease and T2DM were significantly greater in EH patients with carotid atherosclerosis than those without （all P〈0.05）. Logistic regression results showed that EFV, age and history of T2DM were positively correlated with carotid atherosclerosis.

关 键 词：心外膜脂肪 高血压 颈动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]