血清IL-2和IL-6水平变化与丙型肝炎致肝硬化和癌变的相关性研究  

Correlation between changes of serum IL-2 and IL-6 levels and HCV induced liver cirrhosis and cancer

作　　者：李壮[1] 覃后继[2] 潘国刚[2] 

机构地区：[1]右江民族医学院附属医院检验科,广西百色533000 [2]右江民族医学院附属医院感染科,广西百色533000

出　　处：《临床和实验医学杂志》2015年第3期199-201,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清白细胞介素-2(IL-2)和白细胞介素-6(IL-6)水平变化与丙型肝炎(丙肝)致肝硬化和癌变的相关性。方法从2012年10月至2013年10月收治的丙型肝炎患者中随机选择31例,分慢性丙型肝炎组、丙肝后肝硬化组以及丙肝相关性肝癌组,另选择18例健康者作为对照组。检测所有研究对象的血清丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、IL-2和IL-6水平,并进行比较分析。结果较之正常对照组,慢性丙型肝炎组和丙肝后肝硬化组以及丙肝相关性肝癌组的ALT和TBIL水平均出现显著上升的情况,差异均有统计学意义(均P<0.05)。而丙肝相关性肝癌组ALT水平显著低于慢性丙型肝炎组和丙肝后肝硬化组,差异均有统计学意义(均P<0.05)。较之正常对照组,慢性丙型肝炎组和丙肝后肝硬化组以及丙肝相关性肝癌组的IL-2水平均出现显著下降的情况,IL-6水平则出现显著上升,差异均有统计学意义(均P<0.05)。且随着疾病的发展,慢性丙型肝炎组丙肝后肝硬化组丙肝相关性肝癌组的IL-2水平呈逐渐下降情况,IL-6水平则出现逐渐上升情况。结论血清IL-2和IL-6水平变化与丙肝致肝硬化和癌变之间存在一定的相关性。Objective To investigate the correlation between serum levels of interleukin- 2（ IL- 2） and interleukin- 6（ IL- 6） and HCV induced liver cirrhosis and hepatocellular carcinoma（ HCC）. Methods Thirty- one hepatitis C patients treated in our hospital from October 2012 to October 2013 were randomly selected. The patients were divided into chronic hepatitis C group,hepatitis C cirrhosis group and HCV- related HCC group; 18 healthy subjects were as control. Serum alanine aminotransferase（ ALT）,total bilirubin（ TBIL）,IL- 2 and IL- 6 levels were detected and compared. Results Compared with the normal control group,ALT and TBIL levels were significantly increased in all three patient groups,there were significant differences（ all P 0. 05）,whereas ALT level was significantly lower in HCV- related HCC group than those in chronic hepatitis C group and hepatitis C cirrhosis group,there were significant differences（ all P 0. 05）. Compared with normal control group,IL- 2 level was significantly decreased,but IL- 6 level was significantly increased in all three patients groups,there were significant differences（ all P 0. 05）. Along with the progression of the disease,IL- 2 level was gradually decreased whereas IL- 6 level was gradually increased in chronic hepatitis C group,hepatitis C cirrhosis group and HCV- related HCC group. Conclusion Changes of serum IL- 2 and IL-6 levels are associated with the development of HCV C cirrhosis and HCV- related HCC.

关 键 词：丙型肝炎 白细胞介素 肝硬化 癌变 相关性 

分 类 号：R512.63[医药卫生—内科学]