孕妇幽门螺旋杆菌感染及其与缺铁性贫血的相关性  

Clinical study on the relationship between Helicobacter pylori infection and iron deficiency anemia in gravidas

作　　者：黄越前[1] 

机构地区：[1]广州医科大学附属第三医院消化内科,广东广州510150

出　　处：《临床和实验医学杂志》2015年第3期245-248,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨幽门螺杆菌(Hp)感染与孕妇缺铁性贫血(IDA)的关系及其治疗方法。方法选择2011年1月至2014年3月门诊或住院的90例确诊IDA孕妇为研究组,随机抽取了100例无IDA的孕妇作为对照组,均进行13C呼气试验。将90例IDA患者中Hp阳性的44例随机平分成A、B组,Hp阴性的46例为C组,A组给予抗Hp+多糖铁复合物+维生素C治疗,B组和C组给予多糖铁复合物+维生素C治疗。监测治疗前后2周血红蛋白、平均红细胞体积和网织红细胞;治疗12周时的血红蛋白、平均红细胞体积、血清铁和血清铁蛋白情况。结果研究组Hp的感染率为44.9%高于对照组的27.0%,差别有统计学意义(χ2=9.697,P<0.05)。治疗前A组、B组和C组在血红蛋白、平均红细胞体积、网织红细胞、血清铁和血清铁蛋白差异无统计学意义(P>0.05)。治疗2周时A组和C组的网织红细胞、血清铁与铁蛋白均高于治疗前,差异有统计学意义(P<0.05),B组较治疗前无明显变化(P>0.05);治疗12周时三组血红蛋白、平均红细胞体积、网织红细胞、血清铁和血清铁蛋白均高于治疗前(P<0.05);A组和C组的各指标均高于B组(P<0.05)。结论 Hp感染与IDA有一定相关性,抗Hp治疗有助于提高Hp阳性IDA患者的临床疗效。Objective To explore the relationship between Helicobacter pylori（ Hp） infection and iron- deficiency anemia（ IDA） in gravidas and the method to treat IDA combined with Hp infection. Methods Ninety gravidas with IDA and 100 gravidas without IDA were collected from January,2011 to March,2014 as experimental group and control group respectively. All gravidas received13C- breath test. 44 IDA patients associated with Hp positive were divided into groups A and B randomly,while 46 IDA patients with Hp negative as group C. Group A was given anti- Hp therapy ＋ iron polysaccharide complex ＋ vitamin C; group B and C were given iron polysaccharide complex ＋ vitamin C. Blood hemoglobin（ Hb）,mean corpuscular volume（ MCV） and reticulocyte count（ Ret） were detected 2 weeks before and after treatment. Hb,MCV,serum iron（ SI） and serum ferritin（ SF） were monitored at 12 weeks after treatment. Results Hp infection in study group（ 44. 9%） was higher than control group（ 27. 0%）,the difference between two groups had statistical significance（ χ2= 9. 697,P 0. 05）. Hb,MCV,Ret,SI and SF had no difference in group A,B and C before treatment（ P 0. 05）. Ret,SI and SF were higher after two weeks of treatment than before treatment in group A and C,the differences had statistical significance（ all P 0. 05）,while no statistical significance was found in group B（ P 0. 05）. After 12 weeks of treatment,Hb,MCV,Ret,SI and SF in 3 groups were all higher than those before treatment,the differences had statistical significance（ all P 0. 05）. Hb,MCV,Ret,SI and SF in group A and C were higher than group B,the difference had statistical significance（ all P 0. 05）. Conclusion Hp infection and IDA has some relationship. Anti- Hp therapy may improve treatment effect in gravidas of IDA associated with Hp infection.

关 键 词：妊娠 缺铁性贫血 幽门螺杆菌 感染 

分 类 号：R714.25[医药卫生—妇产科学]