益气活血通腑泄浊法对慢性肾脏病患者蛋白质能量消耗状态的影响  

Effect of Yiqihuoxue Tongfu Xiezhuo on Chronic Kidney Disease Patients with Protein Energy Wasting State

作　　者：桂志红[1] 张小如[1] 廖益飞[1] 吴凌慧[1] 彭健韫[1] 许伟海[1] 项美娟[1] 兰乐健[1] 

机构地区：[1]浙江省丽水市人民医院肾脏科,丽水323000

出　　处：《中国中西医结合肾病杂志》2015年第1期27-29,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：浙江省丽水市科技计划基金资助项目(No.2012ZC041);浙江省中医药科技计划项目(No.2012ZA134)

摘　　要：目的:探讨益气活血通腑泄浊法对慢性肾脏病患者蛋白质能量消耗状态的影响。方法:以76例慢性肾脏病5期(chronic kidney diseases 5,CKD5期)非透析患者为研究对象,随机分为两组,治疗组43例、对照组33例,对照组的病人进行常规治疗,治疗组的病人在对照组治疗的基础上加具有益气活血通腑泄浊作用的肾康注射液。SGA评分及人体测量学用于评估患者的营养状态,同时检测血清总蛋白、白蛋白、Hs-CRP、TNF-α和IL-6等指标。结果:经相应的治疗4周后,治疗组营养不良患病率为20.9%;对照组营养不良者患病率为42.4%。治疗组营养状况较对照组明显改善(P<0.05)。治疗组血清白蛋白、前白蛋白、红细胞、血红蛋白及GFR均明显上升,体重指数和MAC均明显升高(P<0.05)。Hs-CRP、IL-6水平明显下降(P<0.05)。结论:降逆泄浊、益气活血法能有效改善慢性肾脏病非透析患者蛋白质能量消耗状态,为今后治疗提供临床对策。Objective：To investigate the effect of Yiqihuoxue tongfu Xiezhuo on Chronic Kidney Disease patients with pro- tein energy wasting state. Methods：76 CKD5 non - dialysis patients came from nephrology division were studied. All the patients were randomly divided into two groups. 43 were in the treatment group, 33 were in the control group. Patients in the control group re- ceived conventional treatment. Patients in the treatment group plus Shenkang injection, which with the role of Yiqihuoxue tongfu Xiezhuo. The Subjective and Global Assessment （SGA） were assessed simultaneously by two trained physician. The anthropometry, inflammation makers and biochemical assays were measured. Comparing different groups of PEW state. Results：4 weeks later, there were 9 patients with malnutrition（20.9% ） in the treatment group, while there were 14 in the control group（42.4% ）, the treatment group malnutrition were improved（ P 〈 0.05 ）. The level of Serum albumin, prealbumin, erythrocytes, hemoglobin and the index of BMI, MAC were increased, while the level of Hs - CRP, IL - 6 were decreased in the treatment group （ P 〈 0.05）. Conclusion： Yiqi- huoxue tongfu Xiezhuo can significantly improve protein energy wasting state of Chronic Kidney Disease patients, which can provide clinical countermeasures for future treatment.

关 键 词：慢性肾脏病 蛋白质能量消耗状态 营养不良 微炎症 SGA评分 

分 类 号：R285.6[医药卫生—中药学]