前列腺疾病吸入5%二氧化碳混合气体BOLD-MRI与微血管特征的对照研究  

The correlative study of carbogen breathing BOLD-MRI and features of micro-vascular of prostatic disease

作　　者：陈化峰 焦自梅 高珊珊[1] 胡娜[1] 王锡臻[1] 刘金刚[1] 李莉莉[1] 王滨[1,3] 

机构地区：[1]潍坊医学院附属医院影像中心,山东潍坊261031 [2]烟台山医院放射科 [3]滨州医学院影像医学与核医学

出　　处：《实用放射学杂志》2015年第2期262-264,341,共4页Journal of Practical Radiology

基　　金：国家自然科学基金（81171303,30470518）;山东省自然科学基金（ZR2009C1.046.ZR2010HQ029）;山东省优秀中青年科学家科研奖励基金（BS2012YY038）;山东省卫生厅科技发展项目（2011WSB29009,2011HW067）;山东省科技攻关项目（2007GG30002032.2008GG30002004）;潍坊医学院博士科研启动基金（2009）.

摘　　要：目的：探讨吸入5%二氧化碳混合气体BOLD-MRI与前列腺增生（BPH）和前列腺癌（PCa）中微血管特征的对应关系。方法采用美国 GE Signa Excite HD 3.0T超导型磁共振成像仪和腹部相控阵线圈,在吸入5%二氧化碳混合气体行 BOLD-MRI。画取正常前列腺外周带（PZ）、中央腺区（CZ）、BPH 和PCa感兴趣区（ROI）,记录时间-信号强度曲线（TIC）和信号强度平均增加率。免疫组化分析BPH 和PCa微血管形态学特征：平均直径、平均面积、平均周长及异型指数。结果 CZ、PZ、BPH 及 PCa 区信号强度于吸入混合气体后高于吸入混合气体前（P〈0.05）；吸入混合气体后正常 CZ、PZ、BPH 及 PCa 区的相对平均信号强度增加率分别为（5.07±1.08）%、（2.78±1.13）%、（6.44±2.02）%和（1.77±0.40）%,BPH 和PCa组织中的 MVD数分别为12.32±3.14和30.22±11.19（P〈0.01）；PCa血管的平均直径、平均面积、平均周长及异型指数均小于 BPH 的相应指标（P〈0.01）。结论前列腺疾病吸入混合气体BOLD-MRI表现与组织的微血管特征有关,有助于评价组织微血管结构功能状态。Objective To investigate the relationship between micro-vascular features and carbogen breathing BOLD-MRI in be-nign prostatic hyperplasia （BPH）and prostate cancer （PCa）.Methods Carbogen breathing BOLD-fMRI was performed using a 3.0 Tesla superconducting magnetic scanner （GE）equipped with a phased-array multi-coil.The regions of interest （ROI）of central zone （CZ）,peripheral zone （PZ）,BPH and PCa were drawn.The relative increase signal rates and time signal intensity curve （TIC） were recorded.The average diameter,area,circumference and special shape index of micro-vascular were analyzed using immunohis-tochemical stain.The relationship between micro-vascular features and BOLD-MRI was analyzed using SPSS 1 1 .5 .Results The sig-nal intensities of CZ,PZ,BPH and PCa during carbogen breathing were higher than those during air breathing （P〈0.05）.The rela-tive increasing rate of TIC of CZ,PZ,BPH and PCa after carbogen breathing were （5.07±1.08）%,（2.78±1.13）%,（6.44± 2.02）% and （1.77±0.40）% （P〈0.05）.The mean MVD of BPH and PCa were 12.32±3.14/field and 30.22±11.19/field （P〈0.05）.The average diameter,area,circumference and special-shape index of PCa were lower than those of BPH （P〈0.05）.Conclu-sion Carbogen inhaling BOLD-MRI is related with the micro-vascular structures in BPH and PCa,which will have potential to eval-uate the function and maturity of micro-vascular.

关 键 词：前列腺癌 血氧水平依赖 功能磁共振成像 血管生成 

分 类 号：R737.25[医药卫生—肿瘤] R445.2[医药卫生—临床医学]