艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望  

Moxibustion: its outlook in the intestinal flora and mucosal immunity for regulation of irritable bowel syndrome

作　　者：赵继梦[1] 黄艳[1] 窦传字[1] 王硕硕[2] 王晓梅[1] 李垠和[1] 包春辉[1] 周次利[1] 翁志军[1] 陆嫄[1] 吴焕淦[1] 

机构地区：[1]上海中医药大学,上海市201203 [2]上海中医药大学附属上海市中西医结合医院,上海市200082

出　　处：《中国组织工程研究》2015年第2期289-293,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家重点基础研究发展计划(973计划)资助项目(2015CB554500);国家自然科学基金青年基金项目资助(81403474);上海市自然科学基金资助项目(14ZR1438700)~~

摘　　要：背景:肠道菌群在宿主肠道内寄生,与肠黏膜免疫屏障相互作用,相互影响,在机体内肠道内环境稳态的调解中起着重要作用。目的:从肠道菌群失调和黏膜免疫激活角度,探讨肠道菌群在肠易激综合征发病环节中的作用及其艾灸治疗肠易激综合征的作用机制。方法:以"肠易激综合征,肠道菌群,肠道黏膜免疫,艾灸"为中文检索词,以"irritable bowel syndrome,intestinal flora,intestinal immune,moxibustion"为英文检索词,应用计算机在中国知网、维普和Pub Med数据库检索2001年10月至2014年10月的相关文献,并进行筛选、归纳和总结。结果与结论:共纳入37篇符合标准文献,其中中文文献15篇,英文文献22篇。文章阐述了肠道菌群失调和肠黏膜免疫在肠易激综合征发病的病理生理过程中发挥的重要作用,肠道菌群失调可影响机体对直肠扩张刺激的感觉阈值、内脏敏感性等。艾灸可从多环节、多靶点调节机体生理平衡,在改善肠易激综合征各项症状,尤其是内脏高敏感性腹痛方面凸显优势。BACKGROUND：The interaction and mutual influence of intestinal flora in the host intestine with mucosal immune barrier play an important role in the homeostasis regulation within the intestine. OBJECTIVE：To explore the role of intestinal flora in the pathogenesis of irritable bowel syndrome and the mechanism of moxibustion in the treatment of irritable bowel syndrome from the aspects of intestinal flora imbalance and mucosal immune activation. METHODS：With the key words of “irritable bowel syndrome, intestinal flora, intestinal immune, moxibustion” in Chinese and in English, respectively, a computer-based search was performed for articles published in CNKI, VIP and PubMed databases from October 2001 to October 2014. After the initial screening, the reserved articles were further detailed, summarized and concluded. RESULTS AND CONCLUSION：Totaly 37 articles were colected, including 15 in Chinese and 22 in English. The analysis results showed that, the imbalance of intestinal flora and mucosal immune can play an important role in the pathogenesis of irritable bowel syndrome, and the former one can affect the body’s feeling of rectal distension threshold and visceral sensitivity. Moxibustion excels at improvement of the symptoms of irritable bowel syndrome, particularly abdominal pain with high visceral sensitivity, by regulating the body’s physiological balance from multi-link and multi-target aspects.

关 键 词：组织构建 组织工程 肠易激综合征 肠道菌群 肠道黏膜免疫 艾灸疗法 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]