股骨头坏死模型动物血清降钙素基因相关肽水平的变化  

Changes in serum calcitonin gene-related peptide levels in animal models of femoral head osteonecrosis

作　　者：黄涛[1] 凯赛尔江.艾合买提 崔泳[1] 

机构地区：[1]新疆医科大学第五附属医院骨科,新疆维吾尔自治区乌鲁木齐市830011

出　　处：《中国组织工程研究》2015年第5期667-673,共7页Chinese Journal of Tissue Engineering Research

基　　金：新疆维吾尔自治区青年科创基金(2013Y11)~~

摘　　要：背景:降钙素基因相关肽是肽能神经分泌的一种神经肽,具有多种重要的生理功能,在骨组织的正常代谢、骨缺损的修复及重建过程中起着重要的作用。目的:观察股骨头坏死模型动物血清降钙素基因相关肽水平的变化。方法:选用新西兰大白兔45只,随机分为3组,分别为激素建模组,液氮建模组,正常对照组,并于造模后第4,6,8,9,10周测定血清降钙素基因相关肽水平,于造模后第9,10周进行病理学检测。结果与结论:激素造模组、液氮造模组在实验8周后病理检测出现明确的骨坏死区且血清降钙素基因相关肽水平明显高于正常对照组,表明股骨头坏死可能与血清降钙素基因相关肽水平的变化具有高度相关性。BACKGROUND：Calcitonin gene-related peptide is a peptide secreted from neuropeptides, has multiple important physiological functions, and plays a key role in normal metabolism of bone tissue, bone defect repair and reconstruction. OBJECTIVE：To observe the changes in the levels of serum calcitonin gene-related peptide of animal models of osteonecrosis of the femoral head. METHODS：A total of 45 New Zealand white rabbits were randomly divided into three groups：hormone modeling group, liquid nitrogen modeling group and normal control group. At 4, 6, 8, 9 and 10 weeks after model establishment, serum calcitonin gene-related peptide levels were determined. At 9 and 10 weeks, pathological detection was performed. RESULTS AND CONCLUSION：Clear bone necrosis was visible at 8 weeks. Simultaneously, serum calcitonin gene-related peptide levels were significantly higher in the hormone modeling and liquid nitrogen modeling groups than in the normal control group. These data suggested that osteonecrosis of the femoral head was possibly strongly associated with serum calcitonin gene-related peptide levels.

关 键 词：实验动物 骨及关节损伤模型 股骨头无菌性坏死 激素 液氮 动物模型 降钙素基因相关肽 

分 类 号：R318[医药卫生—生物医学工程]