血浆同型半胱氨酸水平与脑梗死复发的关系研究  

Study on correlation between serum homocysteine and recurren of cerebral infarction

作　　者：徐国卫[1] 赵敏[1] 高兰[1] 郭达云[1] 王新成[1] 刘欣[1] 

机构地区：[1]郑州大学附属郑州中心医院神经内科二病区,450007

出　　处：《中国实用医刊》2015年第6期36-38,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨血浆同型半胱氨酸（Hcy）水平与脑梗死复发的关系,为脑梗死的防治提供临床依据.方法 收集脑梗死患者245例,根据入院空腹血Hcy水平分为高Hcy组（n=98）及非高Hcy组（n=147）.另选择87例健康体检者为对照组.比较三组患者的一般资料、血Hcy、血脂、病史及复发情况.结果 高Hcy组、非高Hcy组体质量指数、总胆固醇、三酰甘油、血糖、高血压史比例、糖尿病史比例、冠心病史比例均明显高于对照组,高Hcy组年龄、复发率高于非高Hcy组,总胆固醇低于非高Hcy组（P＜0.05）.脑梗死复发的多因素分析显示,Hcy、糖尿病、高血压是脑梗死的独立危险因素.结论 血Hcy升高是导致脑梗死复发的重要危险因素,因此积极控制血Hcy水平对预防脑梗死复发,改善患者预后具有积极的临床意义.Objective To investigate the relationship between serum homocysteine levels and recurrence of cerebral infarction,and thus to provide clinical referonces for prevention and treatment of cerebral infarction.Methods Two hundred and forty-five patients with cerebral infarction were selected and divided into high Hcy group （n =98） and non Hcy group （n =147） according to admission fasting blood Hcy level.Another 87 healthy volunteers were selected as control group.The general data of blood Hcy,blood lipid,history and recurrence rate among the three groups were compared.Results The BMI,TG,TC,blood glucose,ration of hypertension history,diabetes history,history of coronary heart disease in high Hcy group,non Hcy group,non high were significantly higher than those of control group; the age and recurrence rate were higher than those of non Hcy group ; the TC was lower than that of non Hcy group （P 〈 0.05）.Multivariate analysis of cerebral infarction recurrence showed Hcy,diabetes mellitus,hypertension were independent risk factors for cerebral infarction.Conclusions The increase of serum Hcy is important risk factors for recurrence of cerebral infarction,so blood Hcy level control can prevent recurrence of cerebral infarction,and it has positive clinical significance in improving the prognosis.

关 键 词：同型半胱氨酸 脑梗死 复发 

分 类 号：R587.1[医药卫生—内分泌]