不同剂量中/长链脂肪乳对早产儿及低出生体质量儿的疗效及安全性  

Clinical Curative Effect and Safety of MCT/LCT Fat Emulsions at Different Doses in Preterm and Low Birth Weight Infants

作　　者：袁静[1] 何缦 丁武君 

机构地区：[1]嘉兴市妇幼保健院儿科,浙江嘉兴314051

出　　处：《中国药师》2015年第3期444-445,共2页China Pharmacist

摘　　要：目的：观察不同剂量中/长链脂肪乳对早产儿及低出生体质量儿生长发育的影响。方法：76例早产或低出生体质量儿随机分为观察组（40例）与对照组（36例）,在出生后12～24 h内给予中/长链脂肪乳、氨基酸、葡萄糖注射液等治疗,其中观察组中/长链脂肪乳从2.0 g·kg-1·d-1始,以0.5 g·kg-1·d-1递增,逐渐增至3.0 g·kg-1·d-1;对照组中/长链脂肪乳从0.5 g·kg1·d-1始,以0.5 g·kg-1·d-1递增,逐渐增至3.0 g·kg-1·d-1。两组疗程均为7 d。监测两组新生儿体质量增长情况及治疗后血清总胆红素、直接胆红素、丙氨酸氨基转移酶、总胆固醇、三酰甘油及血糖等指标的变化。结果：观察组恢复出生体质量时间（4.38±0.93）d,明显短于对照组的（6.81±1.90）d,恢复后体质量增长幅度（30.41±1.81）g·kg-1·d-1,也明显高于对照组,差异均有统计学意义（P〈0.05）,两组患儿治疗7 d后血生化指标差异无统计学意义（P〉0.05）。结论：早期大量应用中/长链脂肪乳有利于改善早产儿的早期营养状况。Objective：To analyze the effect of MCT/LCT fat emulsions at different doses on the growth and development of prema-ture and low birth weight infants. Methods： Totally 76 cases of preterm or low birth weight infants were divided into the treatment group （40 cases） and the control group （36 cases）, both groups were given MCT/LCT fat emulsions, amino acid and glucose injec-tions in 12-24 h after the birth. The initial dose of MCT/LCT fat emulsions in the treatment group was 2. 0 g＆#183;kg-1 ＆#183;d-1 and the dose was gradually increased to 3. 0 g＆#183;kg-1 ＆#183;d-1 with 0. 5 g＆#183;kg-1 ＆#183;d-1 progressive increase. The initial dose of MCT/LCT fat emulsions in the control group was 0. 5 g＆#183;kg-1 ＆#183;d-1 , and the dose was increased to 3. 0 g＆#183;kg-1 ＆#183;d-1 with 0. 5 g＆#183;kg-1 ＆#183;d-1 progressive in-crease. The treatment course was 7 days. The neonatal weight, serum total bilirubin, direct bilirubin, alanine aminotransferase, total cholesterol, triacylglycerol and blood glucose were monitored in the two groups. Results：The born body mass recovery time of the ob-servation group was （4. 38＋0. 93） d, which was significantly shorter than that in the control group [（6. 81＋1. 90） d]. After the re-covery, the body weight growth rate of the observation group was （30. 41＋1. 81） g＆#183;kg-1 ＆#183;d-1 , which was significantly higher than that of the control group [（18. 21 ＋2. 08） g＆#183;kg-1 ＆#183;d-1, P 〈0. 05]. After the 7-day treatment, the blood biochemical indices showed no statistically significant difference between the two groups （P〉0. 05）. Conclusion：Early application of MCT/LCT fat emul-sions at high dose is beneficial to the improvement of nutritional status in premature infants.

关 键 词：脂肪乳剂 早产儿 低出生体质量儿 胃肠外营养 

分 类 号：R977.6[医药卫生—药品]