单侧突发性聋慢性期及急性期患者的静息态功能磁共振成像研究  

Study of resting state fMRI on patients with sudden deafness in chronic and acute stage

作　　者：王伟[1] 黄志纯[2] 杨明[2] 刘斌[2] 朱新[2] 冯源[1] 卢春强[1] 

机构地区：[1]东南大学医学院,江苏南京210009 [2]东南大学附属中大医院,江苏南京210009

出　　处：《现代中西医结合杂志》2015年第9期921-923,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金面上项目(30970808);南京市科技发展计划项目(7990000011);东南大学高校基本科研业务费专项资金项目(3290001504)

摘　　要：目的采用低频振幅(ALFF)的方法比较单侧突发性聋慢性期及急性期患者静息态功能磁共振成像(f MRI)的差异。方法选取左侧突发性聋2年后的慢性期患者18例(慢性期组)及左侧突发性聋急性期患者18例(急性期组),分别行静息态f MRI数据采集,用ALFF方法比较2组ALFF值改变的脑区。结果静息状态下,慢性期组右侧岛叶、右侧额下回脑区ALFF值较急性期组增高(P均<0.05),右侧颞中回、左侧颞下回、双侧内侧前额叶、右侧小脑脑区ALFF值较急性期组降低(P均<0.05)。结论单侧突发性聋慢性期患者较单侧突发性聋急性期患者存在静息态下脑功能区自发活动异常。Objective It is to compare the differences of the resting state f MRI between the acute and chronic phase of sudden deafness by low frequency amplitude（ ALFF）. Methods 18 cases with sudden deafness of the left side in chronic phase after deafness for two years were selected into chronic phase group,and 18 cases in acute phase were selected into acute phase group. The data acquisition of resting state f MRI in both groups was performed,respectively. The areas of the brain with changes of low frequency amplitude（ ALFF） value in two groups were compared. Results On the resting state,the ALFF value of the right insula,right superior temporal gyrus regions in chronic phase group were increased markedly than that in acute phase group（ all P〈0. 05）,and the ALFF value of the right middle temporal gyrus,left inferior temporal gyrus,bilateral medial frontal gyrus,right cerebellum regions in chronic phase group were markedly reduced than that in acute phase group（ all P〈0. 05）. Conclusion Patients with sudden deafness in chronic phase exists cerebral function abnormal of spontaneous activity under the resting state compare to acute phase group.

关 键 词：突发性聋 静息态f MRI 低频振幅 

分 类 号：R445.2[医药卫生—影像医学与核医学]