神经精神性系统性红斑狼疮相关自身抗体的研究进展  

Research Progress in Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus

作　　者：段新旺[1] 张秀灵[1] 黄清水[2] 尚静静[1] 毛绍园 

机构地区：[1]南昌大学第一附属医院风湿免疫科,南昌330006 [2]南昌大学第一附属医院检验科,南昌330006

出　　处：《南昌大学学报（医学版）》2015年第1期84-87,共4页Journal of Nanchang University：Medical Sciences

摘　　要：神经精神性系统性红斑狼疮(NPSLE)的发病机制目前普遍认为是直接或间接的多种免疫机制作用的结果。NPSLE发病的不同表现形式与多种自身抗体相关,可能存在以下几种相关自身抗体:抗神经元抗体、抗磷脂抗体、抗NR2抗体、抗核糖体P蛋白抗体、抗微管相关蛋白2抗体、抗内皮细胞抗体、抗胶质原纤维酸性蛋白抗体。这些自身抗体可能成为提示或预测NPSLE的特异标记物,值得进一步探讨和证实。The direct and indirect immune mechanisms have been revealed in the pathogenesis of neuropsychiatric systemic lupus erythematosus（NPSLE）.Different manifestations of NPSLE are associated with the autoantibodies.There may be several types of autoantibodies in NPSLE,including anti-neuronal antibodies,anti-phospholipid antibodies,anti-NR2 antibodies,anti-ribosomal P antibodies,anti-microtubule-associated protein-2antibodies,anti-endothelial cell antibodies and anti-glial fibrillary acidic protein.These autoantibodies may be used as the specific markers for NPSLE.However,their efficacy in predicting NPSLE needs to be further investigated and confirmed.

关 键 词：神经精神性系统性红斑狼疮 自身抗体 诊断 

分 类 号：R593.241[医药卫生—内科学]