聚乙二醇200相转移催化合成6-甲基尿嘧啶  

Catalytic Synthesis of 6-Meyhyl Uracil with PEG 200

作　　者：邢晓轲[1] 李建辉[2] 卫世乾[3] 

机构地区：[1]许昌职业技术学院园林园艺系,河南许昌461000 [2]平顶山教育学院,河南平顶山467000 [3]许昌学院学报编辑部,河南许昌461000

出　　处：《合成材料老化与应用》2015年第1期71-73,共3页Synthetic Materials Aging and Application

基　　金：河南省重点科技攻关项目(132102210263);河南省科技计划项目(122102210426)

摘　　要：以乙酰乙酸乙酯和尿素为原料,用对甲苯磺酸作催化剂合成6-甲基尿嘧啶,探讨了不同相转移催化剂、带水剂、相转移催化剂用量及脱水缩合时间等因素对反应产物产率的影响。得出最佳工艺条件为:19.8m L乙酰乙酸乙酯、10g尿素,对甲苯磺酸1.2g,150m L石油醚作带水剂,0.3g聚乙二醇200作相转移催化剂,回流脱水缩合8h,产率可达78%。6-meyhyl uracil was synthesized from ethyl acetoacetate and urea with p-toluenesulfonic acid as catalyst. The effects of phase transfer catalysts,water-carrying agents,amount of phase transfer catalyst and reaction time on yield of 6-meyhyl uracil were studied. The optimum conditions were as follows： fixed ratio of raw materials n（ urea） ∶ n（ ethylacetoacetate） = 0. 167 mol ∶ 0. 157 mol = 1. 06 ∶ 1,the amount of p-toluenesulfonic acid 1. 2g;150m L petroleum ether as water-carrying agent; 0. 3g polyethylene glycol 200 as phase transfer catalyst; reaction time 8h; and reaction temperature 72℃,the yield of 6-meyhyl uracil was 78%.

关 键 词：聚乙二醇200 6-甲基尿嘧啶 相转移催化剂 合成 

分 类 号：O626.4[理学—有机化学]