血清25羟维生素D3和C反应蛋白与冠心病的相关性  

Correlation of serum 25-hydroxyvitamin D3 and C-reactive protein with coronary artery disease

作　　者：李晖[1] 高翠荣[2] 李鲁[3] 张莉[4] 张源明[5] 

机构地区：[1]新疆医科大学一附院VIP内科三病区,乌鲁木齐830054 [2]新疆医科大学一附院风湿科,乌鲁木齐830054 [3]新疆医科大学一附院检验科,乌鲁木齐830054 [4]新疆医科大学一附院VIP内科,乌鲁木齐830054 [5]新疆医科大学一附院心脏中心高血压科,乌鲁木齐830054

出　　处：《中华临床营养杂志》2015年第1期8-11,共4页Chinese Journal of Clinical Nutrition

基　　金：国家自然科学基金（81160039）

摘　　要：目的探讨血清25羟维生素D3[25（OH）D3]和C反应蛋白（CRP）与冠心病的相关性。方法选择本院心脏中心疑似冠心病行冠状动脉造影检查的住院患者416例，冠状动脉狭窄Gensini积分表示冠状动脉病变的严重程度，分别检测血清25（OH）D3和CRP。根据冠状动脉造影结果分为正常冠状动脉组246例、稳定型心绞痛组110例、急性冠状动脉综合征（ACS）组60例。结果正常冠状动脉组、稳定型心绞痛组、ACS组血清25（OH）D3分别为（33．15±20．95）、（28．93±16．45）、（15．55±5．70）nmol／L，正常冠状动脉组、稳定型心绞痛组与ACS组比较，差异均有统计学意义（均P〈0．001）；正常冠状动脉组、稳定型心绞痛组、ACS组血清CRP分别为（4．33±0．12）、（5．68±0．25）、（5．73±0．31）mg／L，ACS组、稳定型心绞痛组与正常冠状动脉组比较，差异均有统计学意义（均P〈0．001）。正常冠状动脉组25（OH）D，与CRP及Gensini评分未见相关性；ACS组25（OH）D3与CRP、Gensini评分呈负相关（r=-0．026，P=0．045；r=-0．256，P=0．048），CRP与Gensini评分呈正相关（r=0．459，P〈0．001）；稳定型心绞痛组25（On）D3与CRP、Gensini评分呈负相关（r=-0．211，P=0．027；r=-0．208，P=0．029），CRP与Gensini评分呈正相关（r=0．574，P〈0．001）。结论低水平的25（OH）D3与冠状动脉狭窄病变相关，结合CRP，低25（OH）D3可能通过炎症机制参与了冠心病的发病过程。Objective To identify the potential correlation of serum 25-hydroxyvitamin D3 [ 25 （OH） D3 ] and C-reactive protein （CRP） with coronary artery disease. Methods We measured the serum 25 （OH）D3 and CRP levels in 416 suspected coronary heart disease patients who underwent coronary angiography. Gensini scores were used to assess the severity of coronary stenosis. Based on the results of coronary angiography, the 416 patients were divided into normal group （n = 246） , stable angina group （n = 110） , and acute coronary syndrome （ACS） group （n =60）. Results The serum levels of 25 （OH） D3 in the normal group and stable angina group were significantly higher than that in the ACS gropu [ （33.15 ± 20. 95） nmol/L vs. （15.55 ± 5.7） nmol/L, （28.93 ± 16.45） nmol/L vs. （15.55 ± 5.7） nmol/L, both P 〈0. 001 ]. The CRP level in the normal group was significantly lower than those in the stable angina group and the ACS group [ （4. 33 ±0.12） mg/Lvs. （5.68 ±0.25） mg/L, （4.33 ±0.12） mg/Lvs. （5.73 ±0.31） mg/L, bothP〈0.001]. The serum 25（OH）D3 was not correlated with CRP or Gensini score in the normal group. In the ACS group, the serum 25 （OH） D3 was negatively correlated with CRP level and Gensini score （ r = - 0. 026, P = 0. 045 ; r = - 0. 256, P = 0. 048 ）, while CRP level was positively correlated with Gensini score （ r = 0. 459, P 〈 0. 001 ）. In the stable angina group, the serum 25 （OH） D3 was also negatively correlated with CRP level and Gensini score （ r = - 0. 211, P = 0. 027 ; r = - 0. 208, P = 0. 029 ） , and the latter two were positively correlated （ r = 0. 574, P 〈 0. 001 ）. Conclusions Low serum 25 （OH） D3 levels are associated with coronary artery stenosis. Combining with CRP, it may be involved in the pathogenesis of coronary heart disease through inflammatory mechanism.

关 键 词：冠心病 25羟维生素D3 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]