冠心病慢性心力衰竭患者血浆白介素-10和转化生长因子-β1的研究  

The study of the plasma levels of IL-10,TGF-β1 in patients with coronary heart disease and chronic heart failure

作　　者：王欢[1] 胡元会[1] 孟昊[2] 贾秋蕾 褚瑜光[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京市100053 [2] 北京中医药大学

出　　处：《中国心血管病研究》2015年第2期129-133,共5页Chinese Journal of Cardiovascular Research

基　　金：北京市自然科学基金（项目编号：7122154）

摘　　要：目的 评价血浆白介素-10（IL-10）和转化生长因子-β1（TGF-β1）在冠心病慢性心力衰竭（CHF）过程中的变化和意义.方法 选择2013年8月至2014年2月中国中医科学院广安门医院心内科住院患者125例,其中慢性心力衰竭患者93例,非心力衰竭患者32例,采用酶联免疫吸附法（ELISA）测定血浆IL-10和TGF-β1水平.结果 冠心病CHF组血浆TGF-β1为（219.99±136.70）pg/ml,低于非心力衰竭组的（646.57±248.06）pg/ml,而血浆IL-10为（7.88±3.79）pg/ml,高于冠心病非心衰组的（3.10± 1.92）pg/ml,且两组比较差异均具有统计学意义.结论 IL-10和TGF-β1水平与心衰严重程度密切相关,可作为评价心衰严重程度的指标之一.Objective To determine the levels of plasma interleukin -10 （IL-10） and transforming growth factor-β1 （TGF-β1） in coronary heart disease patients with chronic heart failure. Methods From August 2013 to February 2014, a total of 125 in-patients admitted in Guang＇anmen Hospital of Traditional Chinese A- cademy of Cardiology were enrolled, of whom 93 patients with chronic heart failure, non-heart failure patients 32 people. The plasma levels of IL-10, TGF-1 were measured by enzyme-linked immunosorbent assay （ELISA）. Results The plasma levels of TGF-β1 in chronic heart failure were lower than the non-failure group, while the plasma levels of IL-10 were higher than the non-coronary heart failure group. Conclusion The plasma levels of IL-10, TGF-β1 are closely related to the severity of heart failure and can be evaluated as an indicator of the severity of heart failure.

关 键 词：冠状动脉疾病 慢性心力衰竭 白介素-10 转化生长因子-Β1 IL-10 TGF-Β1 

分 类 号：R541.4[医药卫生—心血管疾病]