复心合剂对慢性充血性心力衰竭患者淋巴细胞β_1-AR mRNA表达的影响及临床观察  

Effect of Fuxin Mixture on β1-ARmRNA Expression in Patients with Chronic Congestive Heart Failure and Clinical Observation

作　　者：薛一涛[1] 刘秀娟[1] 李焱[1] 鲁月凤[2] 李秋实[2] 焦华琛[1] 

机构地区：[1]山东省中医院,山东济南250010 [2]山东中医药大学,山东济南250014

出　　处：《中华中医药学刊》2015年第3期533-536,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273703)

摘　　要：目的:评价具有温阳复心、活血利水作用的复心合剂对慢性心力衰竭(CHF)心阳虚衰证患者淋巴细胞β1-AR mRNA表达的影响及临床治疗效果。方法:60例慢性心力衰竭心阳虚衰证患者,随机分为对照组(缬沙坦组)30例、治疗组(复心合剂组)30例,经6周治疗后,观察患者外周血淋巴细胞β1-AR mRNA表达、6min步行试验(6MWT)、脑钠肽(BNP)及生活质量评分的变化,观察复心合剂改善心衰患者的临床疗效。结果两组心衰患者外周血淋巴细胞β1-AR mRNA表达量较治疗前明显提高(P<0.01);患者6WMT距离较治疗前明显增加(P<0.01),且6WMT心功能分级较治疗前明显改善(P<0.01);患者血浆BNP水平较治疗前明显降低(P<0.01);明尼苏达心力衰竭生活质量评分较治疗前明显降低(P<0.01),患者生活质量明显改善。结论复心合剂能提高心衰患者外周血淋巴细胞β1-AR mRNA的表达,并有效提高CHF患者运动耐量,降低血浆BNP水平,改善生活质量。Objective： To evaluate the influence of Fuxin Mixture on β1- ARmRNA expression of chronic heart failure（ CHF） patients and its effect. Methods： 60 patients with chronic heart failure heart of Yang deficiency failure syndrome were randomly divided into control group（ valsartan group） 30 cases and treatment group（ compound heart mixture group） 30 cases,After treatment for 6 weeks,we observed the peripheral blood lymphocytes β1- ARmRNA expression,6- min walk test（ 6MWT）,brain natriuretic peptide（ BNP） and the change of quality of life score and observed the clinical curative effect of patients with heart failure. Results： Two groups＇ peripheral blood lymphocytes β1- ARmRNA expression was obviously increased（ P〈 0. 01）. 6MWT distance was significantly increased than that before treatment（ P〈 0. 01）. 6MWT and cardiac function were significantly improved than those before treatment（ P〈 0. 01）. Plasma BNP levels in patients were significantly lower than that before treatment（ P〈 0. 01）. Minnesota heart failure quality of life score was significantly lower than that before treatment（ P〈 0. 01）. The patients＇ quality of life improved significantly.Conclusion： Fuxin Mixture can improve heart failure patients＇ peripheral blood lymphocyte β1- ARmRNA expression,increase the exercise tolerance and reduce the plasma BNP level and improve the quality of life.

关 键 词：复心合剂 心阳虚衰证 Β1-AR MRNA表达 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]