丹蛭降糖胶囊对2型糖尿病患者血脂作用有效性的系统评价  

Meta-analysis of Adjusting Blood Lipid of Type 2 Diabetes Mellitus by Danzhi Jiangtang Capsule

作　　者：赵进东[1,2] 丁雷[1] 鲍陶陶[1] 王欢[1] 陆瑞敏[1] 崔李群 谢峰涛 杨雪[3] 方朝晖[1,2] 

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]安徽省中医药科学院,安徽合肥230031 [3]安徽中医药大学,安徽合肥230031

出　　处：《中华中医药学刊》2015年第3期570-573,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家科技部重大专项项目(2010ZX09102);国家科技支撑计划项目(2012BA126B00);国家中医临床研究基地业务建设科研专项(JDZX201201);国家中医药管理局中医药重点学科项目(20091221);国家中医药管理局国家基本公共卫生服务项目(20131012);安徽中医药大学科学研究基金项目(2015qn029);安徽省卫生厅中医药科研项目(2012zy26)

摘　　要：目的:评价丹蛭降糖胶囊对2型糖尿病患者调脂作用的有效性。方法:计算机检索Cochrane图书馆临床对照试验资料库、Pubmed Embase、中国生物医学文献数据库、中国期刊全文数据库、万方期刊数据库等相关资料,按照Cochrane系统评价的方法,客观评价纳入研究的质量,提取有效数据,采用Rev Man 5.2软件进行Meta分析。结果共纳入6个随机对照试验,包括352例患者。结果显示,丹蛭降糖胶囊能降低2型糖尿病患者TG[MD=0.13,95%CI(0.08,0.19),P<0.01],降低TC[MD=0.26,95%CI(0.17,0.35),P<0.01],降低LDL[MD=0.45,95%CI(0.38,0.51),P<0.01],提高HDL[MD=-0.24,95%CI(-0.29,-0.20),P<0.01]。结论:丹蛭降糖胶囊对2型糖尿病患者血脂作用是有效的。Objective： To evaluate the reducing blood lipid efficacy of Danzhi Jiangtang Capsule therapy for type 2 diabetes mellitus. Methods： Randomized controlled trials were electronically retrieved from Cochrane Library,Pubmed Embase,CBM,CNKI,Wanfang Database and so on. All articles were assessed according to the Cochrane Handbook for Systematic Reviews of interventions and then the effective data was analyzed by Rev Man 5. 2 software. Results： Ten randomized controlled trials involving 584 patients were included. Results： Meta- analysis showed that there was statistical difference in the TG[MD = 0. 13,95% CI（ 0. 08,0. 19）,P 0. 01],TC[MD = 0. 26,95% CI（ 0. 17,0. 35）,P 0. 01],LDL[MD = 0. 45,95% CI（ 0. 38,0. 51）,P 0. 01],HDL[MD =- 0. 24,95% CI（- 0. 29,- 0. 20）,P 0. 01]. Conclusion： Danzhi Jiangtang Capsule therapy for type 2 diabetes mellitus is effect.

关 键 词：丹蛭降糖胶囊 2型糖尿病 血脂 系统评价 

分 类 号：R587.1[医药卫生—内分泌]