安徽省2011年0～6岁儿童抗百日咳毒素抗体水平监测  

Surveillance on antibody levels of pertussis in children aged 0 to 6 years in Anhui Province in 2011

作　　者：陈霞[1] 周淑洁[1] 刘丹青[1] 沈永刚[1] 赵月萍[1] 唐继海[1] 

机构地区：[1]安徽省疾病预防控制中心免疫预防科,合肥230601

出　　处：《国际生物制品学杂志》2015年第1期13-16,共4页International Journal of Biologicals

摘　　要：目的 了解安徽省≤6岁健康儿童抗百日咳毒素（pertussis toxin,PT）抗体水平,为评价疫苗接种效果提供依据.方法 采用多阶段随机抽样方法,在全省16个市0～6岁7个年龄组人群中抽取健康儿童1 787人,用ELISA定量检测血清抗PT IgG抗体.各组之间抗体阳性率差异比较采用χ2检验,抗体几何平均浓度（GMC）差异比较采用F检验.结果 2011年安徽省0～6岁儿童中,几乎所有采集的血清均呈现不同的抗体水平,以0岁组最高（10.33 IU/ml）.抗体GMC随免疫后时间的延长有下降的趋势.不同年龄组之间抗体阳性率和GMC差异均有统计学意义（χ2=15.06,P＜0.05;F=7.96,P＜0.01）.不同性别之间抗体阳性率和GMC差异均无统计学意义（χ2=0.98,P＞0.05;Z=0.852,P=0.394）.结论 安徽省0～6岁儿童抗PT IgG抗体水平随年龄的增加而降低,是否需要加强免疫需作进一步研究.Objective To understand levels of antibody to pertussis toxin （PT） in healthy children under 6 years old in Anhui Province to provide a basis for evaluation on efficacy of vaccination.Methods In all 16 districts,1 787 healthy children from 0 to 6 years were selected by a multi-stage stratified random sampling method.Serum anti-PT IgG was detected by ELISA.Differences in positive rates and geometric mean concentrations （GMCs） of anti-PT antibody among the groups were compared using χ2 test and F test,respectively.Results The levels of antibody varied in almost all sera collected from children aged 0-6 years in Anhui Province with the highest GMC in 0 year group （10.33 IU/ml） and declined with time after vaccination.The differences of antibody positive rates and GMCs among different age groups were statistically significant （χ2 =15.06,P〈0.05; F=7.96,P〈0.01）.However,there was no significant difference of antibody positive rate and GMC between different genders （χ2 =0.98,P〉0.05; Z=0.852,P=0.394）.Conclusions The level of anti-PT IgG in healthy children aged 0-6 years in Anhui Province decreases with age.Further investigations are needed to decide whether a booster immunization is necessary.

关 键 词：白喉-破伤风-百日咳菌苗 免疫 主动 百日咳毒素 

分 类 号：R511.1[医药卫生—内科学]