六味地黄丸联合银杏叶片对2型糖尿病患者糖尿病并发症的影响  

Effects of Liuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets on complications of type 2 diabetes mellitus

作　　者：吴亚平[1] 付丽媛[1] 郭琳[1] 余江毅[2] 马建华[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)内分泌科,210006 [2]江苏省中医院内分泌科,南京210029

出　　处：《国际中医中药杂志》2015年第3期213-216,共4页International Journal of Traditional Chinese Medicine

基　　金：国家十一五支撑计划（2006BAI04A03-1）

摘　　要：目的：探讨六味地黄丸与银杏叶片联合应用对2型糖尿病（type 2 diabetes mellitus, T2DM）患者糖尿病并发症的影响。方法收集2011年3－9月南京医科大学附属南京医院内分泌科收治的T2DM患者78例，按随机数字表法分为2组，每组39例。常规治疗组口服降糖药或胰岛素控制，中药治疗组在常规治疗基础上加用六味地黄丸和银杏叶片。分别于治疗前，治疗后12个月、36个月监测颈动脉内膜中层厚度（intima-media thickness, IMT）、双足振动感觉阈值（vibration perception threshold, VPT）及糖尿病视网膜病等情况。结果治疗后12个月，中药治疗组左足VPT明显低于常规治疗组[（13.98±4.38）V比（18.70±2.43）V；t＝2.764，P＝0.008]。治疗后36个月，中药治疗组颈动脉 IMT[左侧：（0.70±0.10）mm比（0.81±0.16）mm，t＝3.120，P＝0.003；右侧：（0.73±0.12）mm比（0.81±0.17）mm，t＝2.286，P＝0.026]；VPT[左足：（14.82±6.45）V 比（20.63±9.75）V，t＝2.714，P＝0.009；右足：（16.73±7.10）V 比（20.73±10.35）V，t＝2.001，P＝0.048]，以及糖尿病视网膜病发生率[35.9%（14/39）比53.8%（21/39）；χ2＝5.804， P＝0.016]均明显低于常规治疗组。结论六味地黄丸联合银杏叶片可有效减缓T2DM患者糖尿病并发症的进展。Objective To investigate the effects ofLiuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets on diabetic complications in patients with type 2 diabetes mellitus （T2DM）. Methods Seventy-eight patients with T2DM were randomized into a TCM treatment group and a conventional treatment group by random number table method, 39 in each group. The patients in the conventional treatment group were regularly using antihyperglycemic drugs or insulin. On the basis of conventional treatment group, the patients in the TCM treatment group were additionally treated withLiuwei-Dihuang Pills and Ginkgo Biloba Leaves Extract Tablets. Intima-media thickness （IMT） of internal carotid artery, vibration perception threshold （VPT） and diabetic retinopathy in both groups were detected before the treatment, 12 and 36 months after the treatment.Results The VPT in the left foot 12 months after the treatment in the TCM treatment group were significantly lower than that in the conventional treatment group （13.98 ±4.38 Vvs. 18.70 ±2.43 V;t=2.764, P=0.008）. IMT of internal carotid artery （left： 0.81 ± 0.16 mmvs.0.70 ± 0.10 mm,t=3.120,P=0.003; right： 0.81 ± 0.17 mmvs. 0.73 ± 0.12 mm,t=2.286,P=0.026）, VPT （left foot： 14.82 ± 6.45 Vvs. 20.63 ± 9.75 V,t=2.714, P=0.009; right foot： 16.73 ± 7.10 Vvs. 20.73 ± 10.35 V,t=2.001,P=0.048） and incidence of diabetic retinopathy （35.9%vs. 53.8%;χ2=5.804,P=0.016） 36 months after the treatment in the TCM treatment group were significantly lower than those in the conventional treatment group.ConclusionsLiuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets can effectively reduce the progression of diabetic complications in patients with T2DM.

关 键 词：六味地黄丸 银杏叶 糖尿病 2型 糖尿病并发症 

分 类 号：R259[医药卫生—中西医结合]