复方丹参注射液不良反应文献分析  

Literature analysis of adverse reaction induced by compound Danshen injection

作　　者：倪建腾[1] 钟萌[1] 赵奎君[1] 

机构地区：[1]首都医科大学附属北京友谊医院中药剂科,北京100050

出　　处：《国际中医中药杂志》2015年第3期269-271,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的分析复方丹参注射液的不良反应情况、特点及规律，为临床合理用药提供参考。方法以复方丹参注射液为检索词，检索中国学术期刊数据库（万方数据库）、中国期刊全文数据库（CNKI）、中国生物医学文献数据库（SinoMed）、维普中文科技期刊数据库1989-2013年的不良反应病例报道，记录患者年龄、性别、病史、用药剂量、用药时间、不良反应类型的相关数据，并进行分析。结果共检索121篇文献，148份病历。复方丹参注射液的不良反应发生率男性高于女性，因原发病史多为心脑血管疾病，年龄偏高，故与年龄无必然联系；不良反应发生时间多发在用药后5～20min，不良反应为主要过敏反应。结论复方丹参注射液临床应用时，应注意患者体质、性别与用药时间，减少配伍应用，以减少不良反应的发生。Objective In order to investigate the situation application of compound Danshen injection （CDI） in the treatment and to provide reference for clinical rational use. Methods Adverse drug reactions （ADR） report literatures through WANFANG DATA, VIP DATA and CNKI from 1989 to 2013 with （CDI） were retrieved the data including patient age, gender, medical history, dosage, medication time and ADR type were got and analyzed. Results One hundred and twenty-one literatures with one hundred and forty-eight ADR report cases wore retrieved. The ADR of （CDI） rate of male was higher than female. The original disease causes were cardiovascular and cerebrovascular diseases. The age, a rather elderly bunch, was not associated with the disease. The frequent onest time of adverse reaction was in 5-20 min after medication, and allergic reaction was the main adverse reaction. Conclusion The ADR of CDI should not be ignored. Patients constitution, gender, medication time and the combined application should he pay more attention to reduce the incidence of ADR and ensure the drug safety.

关 键 词：复方丹参注射液 不良反应 中成药 

分 类 号：R286[医药卫生—中药学]