2型糖尿病患者尿白蛋白/肌酐与肾素-血管紧张素系统活性相关性研究  

Study on the relativity between A/C and activity of renin-angiotensin system on patients with diabetes

作　　者：张若兰[1] 

机构地区：[1]哈励逊国际和平医院心内科,河北衡水053000

出　　处：《中国医学前沿杂志（电子版）》2015年第1期108-110,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的研究2型糖尿病患者尿白蛋白/肌酐(A/C)与肾素-血管紧张素系统(RAS)活性的相关性。方法选择160例2型糖尿病患者行A/C检测,将其分为A/C正常组96例(A/C≤30 mg/g)及A/C异常组64例(A/C>30 mg/g),选择健康志愿者作为对照组(60例),检测三组研究对象静脉血RAS指标并比较各组的差异性,采用Logistic回归分析患者A/C与RAS各指标的相关性。结果A/C异常组及A/C正常组患者静脉血肾素(PRA)、血管紧张素Ⅱ(AngⅡ)及醛固酮水平均高于对照组,A/C异常组患者静脉血PRA、AngⅡ及醛固酮水平均高于A/C正常组,差异均具有显著性(P<0.05)。Logistic回归分析显示,A/C与静脉血PRA无明显相关性(P>0.05),A/C与AngⅡ、醛固酮水平呈正相关(r=0.495,0.316;P=0.000,0.002)。结论 2型糖尿病患者A/C与RAS活性具有相关性,RAS激活可能与2型糖尿病患者肾及血管损伤有关,A/C检测能够反映患者体内RAS激活程度,为2型糖尿病患者微循环损伤的早期发现提供新的指标。Objective To study relativity between ratio of urinary protein to creatinine（A/C） and activity of renin-angiotensinsystem on patients with type 2 diabetes melitus. Method 160 cases of patients with type 2 diabetes melitus were selected and divided into A/C normal group（96 cases） and A/C abnormal group（64 cases） according to weather with normal A/C, and 60 health volunteers were selected as control group, and all patients and voluntary were detected and contrasted with index of RAS between the three groups, then relativity between A/C and index of RAS were analysied with Logistic regression analysis. Result A/C abnormal group and A/C normal group patients with venous renin（PRA）, angiotensin Ⅱ（Ang Ⅱ） and aldosterone levels were higher than control group, A/C abnormal group vein blood of patients with PRA, Ang Ⅱ and aldosterone levels were higher than A/C normal group, the difference was significant（P〈0.05）. Logistic regression analysis showed no significant correlation between the A/C and venous PRA（P〉0.05）, A/C and Ang Ⅱ, aldosterone levels were positively correlated（r = 0.495, 0.316; P = 0.000, 0.002）. Conclusion There is a relativity between A/C and activity of RAS on patients with type 2 diabetes melitus, activation of RAS maybe is a reason of renal and damage, and detecting A/C can reflect degree of RAS activation.

关 键 词：尿白蛋白排泄率/肌酐 2型糖尿病 肾素-血管紧张素系统 血管紧张素Ⅱ 醛固酮 

分 类 号：R587.1[医药卫生—内分泌]