复方丙酸氯倍他索联合他卡西醇治疗寻常型银屑病的疗效  

Efficacy of compound clobetasol propionate combined with tacalcitol on treating psoriasis vulgaris

作　　者：马超[1] 牛丽敏[1] 李淑玲[1] 王伟[1] 

机构地区：[1]安徽省阜阳市人民医院皮肤科,236004

出　　处：《安徽医学》2015年第2期176-178,共3页Anhui Medical Journal

摘　　要：目的观察复方丙酸氯倍他索软膏与他卡西醇软膏联合治疗寻常型银屑病的疗效。方法将112例寻常型银屑病患者按照随机数字法分为研究组和对照组。对照组给予复方丙酸氯倍他索软膏,研究组给予复方丙酸氯倍他索软膏及他卡西醇软膏联合治疗,观察两组的临床治疗效果。结果研究组有效率为91.1%,明显高于对照组71.4%,差异有统计学意义(P<0.05)。治疗后两组的上肢、躯干和下肢的靶损害部位评分较治疗前有明显改善,组间数据比较差异有统计学意义(P<0.05)。研究组与对照组不良反应发生率为1.8%、3.5%,差异无统计学意义(P>0.05)。结论复方丙酸氯倍他索软膏与他卡西醇软膏联合治疗寻常型银屑病效果显著,能有效改善患者临床症状,不良反应少,安全性高,值得临床应用。Objective To investigate the effect of compound clobetasol propionate ointment combined with tacalcitol ointment on treating psoriasis vulgaris.Methods 1 12 patients with psoriasis vulgaris were divided randomly into experiment group and control group. The patients in the experiment group were embrocated with compound clobetasol propionate ointment combined with tacalcitol ointment,while the control group only with compound clobetasol propionate ointment.The clinical efficacy of both groups was observed and recorded.Results The effective rate of the experiment group (9 1.1%)was much higher than the control group (7 1.4%),and the difference was statistically significant (P<0.05 ).The lesion area scores on the trunk,upper and lower limbs of all patients increased evidently after both therapies, and there was significant difference in the scores between the groups (P<0.05 ).The incident rate of adverse reactions in each group was 1.8% and 3.5% respectively,with no significant difference (P>0.05 ).Conclusion Compound clobetasol propionate ointment combined with tacalcitol ointment is farely safe and effective in treating psoriasis vulgaris and improving clinical symptoms,with less side effects for clinical application.

关 键 词：银屑病 寻常型 他卡西醇 复方丙酸氯倍他索 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]