孟鲁司特联合沙丁胺醇气雾剂治疗咳嗽变异性哮喘的临床疗效及对IL-6TNF-α的影响  

Influence of montelukast combined with salbutamol aerosol on IL-6、TNF-α and clinical efficacy in patients with asthma

作　　者：朱明辉[1] 胡广奋[1] 陆婉晖[1] 黎靖麟[1] 

机构地区：[1]广东省广州市第一人民医院鹤洞分院呼吸科,510380

出　　处：《安徽医学》2015年第2期191-193,共3页Anhui Medical Journal

摘　　要：目的探讨孟鲁司特联合沙丁胺醇气雾剂在治疗咳嗽变异性哮喘的临床疗效。方法选取128例咳嗽变异性哮喘患者,随机分为观察组和对照组,对照组仅给予沙丁胺醇气雾剂,观察组采用孟鲁司特联合沙丁胺醇气雾剂治疗,比较两组患者临床疗效、肺功能、咳嗽消失时间及血清细胞因子变化。结果观察组治疗有效率(94.8%)显著优于对照(75.0%),差异有统计学意义(χ2=4.267,P<0.05)。观察组第一秒用力呼气容积(FEV1)、第一秒用力呼气容积/用力肺活量(FEV1/FVC)均显著高于对照组,差异有统计学意义(P<0.05)。观察组平均咳嗽消失时间、血清IL-6、TNF-α水平显著低于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特联合沙丁胺醇气雾剂治疗咳嗽变异性哮喘安全有效。Objective To evaluate the clinical efficacy of montelukast combined with salbutamol aerosol in the treatment of cough variant asthma.Methods 128 patients with cough variant asthma were randomly divided into control group and observation group.Monte-lukast combined with salbutamol aerosol were administrated to the 64 patients in the observation group,and salbutamol aerosol alone was used in the control group.The clinical efficacy,pulmonary function,cough disappeared time,and serum cytokine level of patients in the two groups were assessed and compared.Results The efficacy rate in the observation group was significant higher than that of the control group (94.8% vs 75.0%,χ2 =4.267,P<0.05).The forced expiratory volume in 1 s (FEV1 )and forced expiratory volume in 1 s /forced vital capacity (FEV1/FVC)in the observation group were also significantly higher than those of the control group,and the difference was statisti-cally significant (P<0.05 ).But the average cough disappeared time,serum IL-6 and TNF-αlevel in the observation group were significant-ly lower than the control group,with significant difference between the two groups (P<0.05 ).Conclusion Treatment with montelukast combined with salbutamol aerosol in patients with cough variant asthma is safe and effective,and is worthy of clinical application and promo-tion.

关 键 词：咳嗽变异性哮喘 孟鲁司特 沙丁胺醇 白细胞介素6 肿瘤坏死因子α 

分 类 号：R562.25[医药卫生—呼吸系统]