血清CysC、RBP、NEFA联合检测在2型糖尿病肾病早期诊断中的临床价值  

The clinical value of combined detection of serum Cys C,RBP and NEFA in the early diagnosis of type 2 diabetic nephropathy

作　　者：梁丽娟[1] 洪宝建[1] 方亚奇[1] 张敏霞[1] 

机构地区：[1]浙江省人民医院检验科,浙江杭州310024

出　　处：《中国卫生检验杂志》2015年第4期524-525,528,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清胱抑素C(Cys C)、视黄醇结合蛋白(RBP)、游离脂肪酸(NEFA)检测在2型糖尿病肾病(DN)中的临床价值。方法选取在本院确诊的2型糖尿病患者102例,健康体检者38例。糖尿病组按尿白蛋白分为3组:正常白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组,分析其血清Cys C、RBP、NEFA、血清肌酐(Scr)、尿素氮(BUN)水平,并对结果进行比较分析。结果 2型糖尿病肾病患者血清中Cys C、RBP、NEFA的水平显著高于正常对照组(P<0.05),而Scr、BUN两组间比较差异无统计学意义(P>0.05)。正常白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组Cys C、RBP、NEFA 3项联合检测的阳性率分别为18.6%、75.0%、100.0%,均高于各单项指标的检测阳性率。结论 2型糖尿病肾病患者中血清Cys C、RBP、NEFA升高明显,联合检测可作为2型糖尿病肾病的早期监控和病变的评估指标。Objective To investigate the clinical value of cystatin C（ Cys C）,retinol- binding protein（ RBP） and non- esterified fatty acid（ NEFA） in type 2 diabetic nephropathy（ DN）. Methods We selected 102 confirmed cases of type 2 diabetes patients and 38 healthy volunteers from our hospital. According to the urine albumin,the diabetes group was divided into three groups： normal albuminuria group,micro- albuminuria group and clinical albuminuria group. The levels of Cys C,RBP,NEFA,creatinine（ Scr） and urea nitrogen（ BUN） in serum were analyzed,and the results were comparatively analyzed.Results The levels of Cys C,RBP and NEFA in the serum of patients with type 2 diabetic nephropathy were significantly higher than that of normal- control group（ P 0. 05）. However,the differences between Scr and BUN were not statistically significant（P 0. 05）. In normal albuminuria group,micro- albuminuria group and the clinical albuminuria group,the positive rate of Cys C,RBP and NEFA were respectively 18. 6%,75. 0% and 100. 0%,when they were tested in joint inspection,and were higher than the single parameter test results. Conclusion In the serum of type 2 diabetic nephropathy,Cys C,RBP and NEFA increased higher significantly. Joint detection can be used as the index of early monitoring and lesions evaluationin type 2 diabetic nephropathy.

关 键 词：血清胱抑素C 视黄醇结合蛋白 游离脂肪酸 联合检测 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]