丹蛭降糖胶囊治疗2型糖尿病血管病变的作用机制研究  

Mechanism research of Danzhijiangtang Capsule curing type 2 diabetic with vascular complications

作　　者：高家荣[1,2] 庄星星 魏良兵[1] 韩燕全[1,2] 

机构地区：[1]安徽中医药大学第一附属医院,国家中医药管理局中药制剂三级实验室,合肥230031 [2]安徽中医药大学药学院,合肥230038

出　　处：《中药药理与临床》2014年第6期143-145,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医临床研究基地业务建设科研专项课题(JDZX2012003)

摘　　要：目的:观察丹蛭降糖胶囊对2型糖尿病血管病变大鼠治疗作用,探索其可能的作用机制。方法:运用高脂饲料喂养结合小剂量链脲佐菌素复制2型糖尿病血管病变大鼠模型。灌胃给药2周后和4周后处死部分大鼠,腹主动脉取血,测血浆糖化血红蛋白、胰岛素、NO、ET-1、PAI、t-PA、PGI2和TXA2的含量,动态观察丹蛭降糖胶囊对2型糖尿病血管病变大鼠的治疗作用。结果:和正常大鼠相比,2型糖尿病血管病变大鼠血浆胰岛素水平降低,糖化血红蛋白升高;模型组大鼠血浆PAI、ET-1和TXA2含量升高,血浆t-PA、NO和PGI2含量则显著降低。给药4周后,丹蛭降糖胶囊1.26(g/kg)组和丹蛭降糖胶囊0.63(g/kg)组可以降低显著血浆PAI、ET-1和TXA2水平,升高血浆t-PA、NO和PGI2。丹蛭降糖胶囊1.26(g/kg)组、0.63(g/kg)组和0.32(g/kg)组均可以降低血糖,丹蛭降糖胶囊1.26(g/kg)组和丹蛭降糖胶囊0.63(g/kg)组可降低糖化血红蛋白水平,丹蛭降糖胶囊1.26(g/kg)组可升高血浆胰岛素水平。结论 :丹蛭降糖胶囊对2型糖尿病血管病变大鼠有防治作用,其机制可能与修复胰岛细胞和血管内皮细胞有关。Objective： Observe the treatment of Danzhijiangtang Capsule on type 2 diabetic with vascular complications rats,to explore its possible mechanism. Method： Using fat diet combined with a small dose of STZ copy type 2 diabetic with vascular complications rat model. After ga- vaged for two weeks and four weeks, some rats were sacrificed, abdominal aortic blood, measured insulin,HbAlc,HA PAI, t-PA, NO,ET- 1 ,PGI2 and TXA2 levels in plasma, dynamic concept Chadan vermiculite hypoglycemic diabetic vascular capsule on 2 lesions in Rats. Dy- namic observation the therapeutic effect of DJC capsule on type 2 diabetic with vascular complications rats. Results： TXA2 ,ET-land PAI lev- els in plasma increased significantly（ P 〈 0.01 ）, t-PA, NO and PGI2 levels in plasma reduced（ P 〈 0.01 ）, insulin levels are significantly low- er than in normal rats compared to the model rats（ P 〈 0.01 ） HbAlc levels are significantly higher than in normal rats compared to the model rats. Administered four weeks later, DJC 1.26 （g/kg） group and DJC 0.63 （g/kg） group can significantly reduce plasma PAI, ET-1 and TXA2 levels, increased plasma t-PA , NO and PGI2 （ P 〈 0.01 ）. DJC 1.26 （g/kg） group, 0.63 （g/kg） group and 0.32 （g/kg） group can lower blood glucose （ P 〈 0.01 ） , DJC 1.26 （g/kg） group and DJC 0.63 （g/kg） group can reduce glycated hemoglobin levels （ P 〈 0.01 ）, DJC 1.26 （g/kg） group may be elevated plasma insulin levels （P 〈 0.05 ）. Conclusion： Danzhijiangtang Capsule could cure type 2 diabetic with vascular complications effectively, possible mechanism may be repairing the islet and endothelial ceils.

关 键 词：丹蛭降糖胶囊 2型糖尿病血管病变 血管内皮细胞 

分 类 号：R259[医药卫生—中西医结合]