质膜组分磷脂酰丝氨酸外翻的分子调控机制  

Molecular regulations of phosphatidylserine eversion in plasma membrane

作　　者：毕丹[1,2] 徐扬[1,2] 逄越[1,2] 李庆伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]辽宁师范大学七鳃鳗研究中心,大连116029

出　　处：《遗传》2015年第2期140-147,共8页Hereditas（Beijing)

基　　金：国家重大基础研究发展规划(973计划)项目(编号:2013CB835304);全国海洋公益项目(编号:201305016);国家自然科学基金项目(编号:31170353;31202020);大连市科技计划项目(编号:2013E11SF056)资助

摘　　要：磷脂酰丝氨酸(Phosphatidylserine,PS)是细胞质膜重要的磷脂成分之一,具有重要的生物学功能。在细胞凋亡及一些特殊的病理条件下,细胞内ATP供能不足,胞浆Ca2+浓度升高,引起PS发生外翻。PS外翻在不同类型细胞中具有不同的生物学功能,且外翻的程度与疾病发展程度密切相关,可作为癌症等多种疾病治疗的靶标。文章综述了细胞质膜中磷脂酰丝氨酸的重要生物学功能和意义、磷脂酰丝氨酸外翻的分子机制及在临床医学方面的应用,以期对未来的功能和临床应用研究提供参考。Phosphatidylserine （PS）, one important phospholipid of cell membranes, has crucial biological functions Under special pathological circumstances such as cell apoptosis, cells cannot generate enough ATP for energy and the concentration of cytoplasmic Ca^2＋ increases, resulting in PS eversion. PS eversion has different biological functions in different cell types. In addition, the degree of eversion is closely associated with the progress of diseases. Therefore, it can be therapeutic targets of cancer and many other diseases. In this review, we summarize the fundamental biological functions of PS, molecular mechanisms of PS eversion, as well as its potential in translational medicine.

关 键 词：磷脂酰丝氨酸 靶标分子 细胞凋亡 磷脂酰丝氨酸外翻 

分 类 号：Q241[生物学—细胞生物学]