滇产复方甘西鼠尾草注射液对大鼠心肌缺血再灌注心脏功能的影响  

Effect of SP+PN on Cardiac Function in Rats with Ischemic Reperfused Myocardium

作　　者：苏彦宏[1] 段为钢[2] 李惠兰[2] 

机构地区：[1]昆明医科大学第一附属医院心内科,云南昆明650032 [2]昆明医科大学药理教研室,云南昆明650500

出　　处：《昆明医科大学学报》2015年第2期15-18,共4页Journal of Kunming Medical University

基　　金：云南省科技厅应用基础研究基金资助项目(98CO67M)

摘　　要：目的探讨滇产复方甘西鼠尾注射液(甘西鼠尾+三七,SP+PN)对大鼠心肌缺血再灌注损伤心功能的影响.方法采用Langendorff离体心脏灌流法.观察缺血、再灌注损伤引起的心功能的改变及药物的作用.结果 SP+PN能显著的增加冠脉流量,增强心肌的收缩力,减慢心率(P<0.05).结论复方甘西鼠尾注射液(SP+PN)有很强的对抗缺血/再灌注对心脏功能损伤的作用,有效地保护心脏功能,提高心脏的顺应性.Objective To investigate the effect of SP＋PN on cardiac function in rats with reperfused ischemic myocardium.Methods Langendorff isolated heart perfused technique was used to build the model. We evaluated the alteration of cardiac function during ischemia,reperfusion and assessed the effect of SP＋PN. Result SP＋PN significantly enhanced the ventrical contractile force,increased coronary flow and reduced the heart rate Conclusion SP＋PN has protective effect on cardiac function against tissue injury associated with ischemia or reperfusion.

关 键 词：复方甘西鼠尾 心肌缺血/再灌注损伤 冠脉流量 心肌收缩力 心率 

分 类 号：R541.4[医药卫生—心血管疾病]