滇东北地区4682例女性人乳头瘤病毒感染及其亚型分型分布调查  

Survey of 4 682 Female Cervical Human Papilloma Virus Infection and The Distribution of Genotype in Northeast of Yunnan

作　　者：沈红[1,2] 程涛[1,2] 王芳 白松[3] 

机构地区：[1]昆明医科大学基础医学院病理学教研室,云南昆明650500 [2]昭通市第一人民医院病理科,云南昭通657000 [3]昆明医科大学第一附属医院干疗科,云南昆明650032

出　　处：《昆明医科大学学报》2015年第3期23-25,共3页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81260361);云南省应用基础研究计划基金资助项目(2010CD079)

摘　　要：目的调查昭通市女性宫颈人乳头瘤病毒(HPV)感染状况,为预防HPV感染和宫颈癌防治提供理论依据.方法收集昭通市第一人民医院2012年5月至2014年8月妇科就诊的4 682例女性患者的宫颈脱落细胞标本,通过HPV基因分型检测对HPV感染情况、亚型分布及其年龄分布特点进行分析.结果 4 682例标本中,HPV总感染率为,高危型HPV感染率为15.4%(721/4 682),在649份阳性标本中,共计检出853株HPV亚型(包括多重感染的重复计算),其中16型16.41%(140/853)、52型14.65%(125/853)、58型10.55%(90/853),低危型HPV感染率为2.82%(132/4 682),以6型4.34%(37/853)、43型3.99%(34/853)、11型3.52%(30/853)为主.HPV的感染率随着年龄增加,呈降低趋势,感染率最高在≤24岁组,检出率为21.52%,各年龄段感染率差异有统计学意义(P<0.05).结论昭通市HPV感染具有明显的年龄分布特点.Objective To investigate the infectious situation of human papilloma virus in female cervix and provide an evidence for prevention and therapy of cervical carcinoma. Methods 4682 cases of specimens of cervical exfoliated epithelial cells from female cervix during 2012.05-2014.08 were collected. HPV infection was identified by the genotype features.The infectious situation of HPV,the distribution of its subtypes and the susceptible age to HPV infection were analyzed based on the genotype features. Results The total prevalence of infection was 13.86%（649/4682）,and the high-risk HPV infection rate was 15.4%（721/4682）. In 649 positive specimens,a total of853 strains of HPV subtypes（including multiple infection of double counting） were detected. The top three subtypes of the High-risk HPV were HPV16（16.41%,140/853）,HPV52（14.65%,125/853） and HPV58（10.55%,90/853）. On the other hand, the low-risk HPV infection rate was 2.82%（132/4682）,of which the top three subtypes were HPV6（4.24%,37/853）,HPV43（3.99%,34/853） and HPV11（3.52%,30/853）. HPV infection rate showed a trend of decrease with the growth of age. In patients 24 years or younger, HPV infection rate was 21.52%. The difference in infectious rate between groups was statistically significant（P 0.05）. Conclusion There is an obvious characteristic in age distribution for HPV infection in Zhaotong, Yunnan province.

关 键 词：人乳头瘤病毒感染 基因分型 宫颈 

分 类 号：R373.9[医药卫生—病原生物学]