百合更年安颗粒长期毒性研究  

Study on Chronic Toxicity of Bai He Geng Nian An

作　　者：翟建英[1] 杨海润[1] 张思玉[1] 朱晓光[1] 陈会丛[1] 李晋生 

机构地区：[1]北京中研同仁堂医药研发有限公司中药复方新药开发国家工程研究中心,100079 [2]北京同仁堂科技发展股份有限公司,100079

出　　处：《首都食品与医药》2015年第2期51-53,共3页Capital Food Medicine

基　　金：首都市民健康项目培育(Z111102067311007)

摘　　要：目的观察百合更年安颗粒的长期毒性,为其安全应用提供参考。方法将大鼠随机分为4组,空白对照组和百合更年安颗粒高(35.784生药/kg/日)、中(17.892 g生药/kg/日)、低(8.946 g生药/kg/日)剂量组,连续给药26周,停药恢复4周,观察大鼠的一般行为、体重增长、食量消耗、血液学及血液生化学指征、尿常规检查、系统尸解及组织病理学诊断。结果长期毒性实验中,与同期空白对照组比较,百合更年安颗粒高、中、低3个剂量组动物行为活动、进食量等检查均未见异常;血液学指标、血液生化指标和尿液指标未发现与供试品有关的异常改变,病理组织学检查未发现与百合更年安颗粒丸相关的异常改变。结论在本实验条件下未观察到明显毒性反应,应用较安全。Objective To study the chronic toxicity of BaiHeGengNianAn in rat. Methods：Rats were randomly divided into control group, high group（35.784g/kg）, middle group（17.892g/kg） and low group（8.946g/kg）.Rats in the day gavage for consecutive 26 weeks, and 4 weeks rest. The general conditions were observed and the related indexes were detected, such as body weight, food consumption, routine control of blood, blood biochemistry,urinalysis;the rats were dissected and precisionly weigh the weight of heart, liver, spleen, lung, renal, brain, adrenal and thymusl, and calculated the ratio of organ to body; the histopathologic examiniation of tissue were examined. Results Compared with control group, No significant differences were observed in rat＆#39;s behaviors,food intake and relative examination indexes, such as routine control of blood, blood biochemistry, urinalysis and organ coefficient. Conclusion BaiHeGengNianAn is safe and have no side-effects in rats.

关 键 词：百合更年安颗粒 长期毒性 大鼠 

分 类 号：R285.5[医药卫生—中药学]