蒙古族居民三种细胞因子与心脑血管事件关系的巢式病例对照研究  

A nested case-control study on the relationship of three kinds of cytokines and risk of cardiocerebrovascular events among Inner Mongolians

作　　者：刘艳[1] 卜晓青[1] 陈秋艳[1] 徐娟[1] 孔凡龙[1] 汪桂艳 张永红[1] 

机构地区：[1]苏州大学医学部公共卫生学院流行病与卫生统计学教研室,215123 [2]厦门市妇幼保健院预防保健科

出　　处：《中华预防医学杂志》2015年第3期254-258,共5页Chinese Journal of Preventive Medicine

基　　金：基金项目：国家自然科学基金（30972531）

摘　　要：目的探讨蒙古族居民同型半胱氨酸（Hcy）、假性血友病因子（vWF）及可溶性细胞间黏附因子（sICAM-1）与心脑血管事件发生的关系。方法于2002年5月至2003年6月获得2589名蒙古族基线人群，对其进行约10年随访。采用巢式病例对照研究方法，以发生的182例心脑血管事件患者作为病例组，在未发生事件的人群中按照年龄、性别和住所进行1：1匹配获取对照。分析Hcy、vwF和sICAM-1与心脑血管事件发生的关系。用条件logistic回归分析方法，计算OR（95％CI）值。结果182例病例组的年龄为（58．4±10．8）岁，182名对照组的年龄为（58．1±10．8）岁。病例组基线血压水平、高血压患病率及高血压家族史均高于对照组（P值均〈0．05），而TC、TG、LDL-C、HDL-C、FPG、吸烟和饮酒率等差异均无统计学意义（P值均〉0．05）。病例组和对照组Hcy的M（P25～P75）分别为10．68（7．84～14．98）、10．02（6．64～13．94）μmol／L，vWF的M（P25～P75）分别为10．88（8．14—14．58）、10．42（7．97—13．50）mg／L，sICAM-1的M（P25～P75）分别为336．48（260．68～409．87）、335．12（269．87—409．87）ng／ml，差异均无统计学意义（Z值分别为0．89、0．94、0．29，P值均〉0．05）。在调整了高血压家族史、高血压、TC、FBG、BMI、吸烟和饮酒率后，条件logistic分析结果表明，与Hcy、vwF、sICAM-1正常者相比，Hcy、vWF、sICAM-1水平升高者发生心脑血管事件OR（95％CI）值分别为1．00（0．52～1．93）、2．37（1．25～4．49）和0．81（0．45～1．47）。结论在蒙古族人群中，vWF水平升高可能增加心脑血管事件的危险胜，Hcy和sICAM-1水平升高与心脑血管事件无关联。Objective To investigate the relationship between homocysteine（Hcy） ,von willebrand factor（vWF）, soluble intercellular adhesion molecule-1 （sICAM-1） and the risk of cardio-eerebrovascular events among Inner Mongolians. Methods A survey was conducted among 2 589 Inner Mongolians from May 2002 to June 2003, and they were followed up for about ten years. The 182 individuals who developed cardio-cerebrovaseular events in the cohort were defined as cases and those whose age, gender and residence 1：1 matched to cases were selected from the individuals who did not developed cardio-eerebrovascular events as controls. Then, a nested case-control study was used to analyze the relationship between Hcy, vWF and sICAM-1 and risk of cardio-cerebrovascular events. Conditonallogistic regression analysis was used to calculate OR values and 95% CI. Results The cases had a higher baseline blood pressure, higher prevalence of hypertension and family history of hypertension compared to controls （ all P values 〈 0. 05 ）, however, there were no significantly different between TC, TG, LDL-C, HDL-C, FBG, smoking and drinking rates（all P values 〉 0. 05 ）. The M（ P25 - P75 ） of Hcy were 10. 68 （7.84 - 14. 98） and 10. 02 （6. 64 - 13.94） μmoL/L, vWFs were 10. 88 （ 8. 14 - 14. 58 ） and 10.42 （7.97 - 13.50） mg/L, sICAM-1were 336.48 （ 260. 68 - 409.87 ） and 335. 12 （ 269. 87 - 409. 87 ） ng/ml. They were not significantly different between the two groups （ Z values were 0. 89, 0. 94 and 0. 29, respectively, all P values 〉 0.05 ）. After adjustment for the family history of hypertension, hypertension, TC, FPG, BMI,smoking and drinking rate, the conditional logistic regression showed that OR （95% C1） of risk of cardio-eerebrovascular events were 1.00 （0. 52 - 1.93 ） , 2. 37 （ 1.25 - 4. 49） , and 0. 81 （0. 45 - 1.47 ） for the participants with increased Hcy, vWF, and sICAM-1, compared with those with normal Hey, vWF, and slCAM-1, respectively. Conclusion In the Inner Mongol

关 键 词：炎症 病例对照研究 心脑血管事件 内皮功能异常 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]