Small-angle X-ray scattering probe of intermolecular interaction in red blood cells  

作　　者：刘广峰 王文佳 徐建华 董宇辉 

机构地区：[1]Beijing Synchrotron Radiation Facility, Institute of High Energy Physics,Chinese Academy of Sciences

出　　处：《Chinese Physics C》2015年第3期83-86,共4页中国物理C（英文版）

基　　金：Supported by National Basic Research Program of China(2009CB918600);National Natural Science Foundation of China(10979005)

摘　　要：With high concentrations of hemoglobin （Hb） in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.With high concentrations of hemoglobin （Hb） in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.

关 键 词：small-angle X-ray scattering protein-protein interaction HEMOGLOBIN 

分 类 号：O434.1[机械工程—光学工程]