心脑通络液对动脉粥样硬化家兔血管内皮病理组织学、超微结构的影响  

Effects of Xinnao Tongluo liquid on pathological histology and ultrastructure of vascular endothelium in rabbits with atherosclerosis

作　　者：吴限[1] 孙靖亮 孙朝军[2] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《湖南中医杂志》2015年第2期125-127,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：黑龙江省自然基金资助项目(编号:D201179)

摘　　要：目的:观察心脑通络液对动脉粥样硬化家兔血管内皮病理组织学、超微结构的影响,探讨心脑通络液对动脉粥样硬化的治疗作用。方法:选取40只新西兰雄性白兔,随机分为5组:假手术组(空白组)、模型组、心脑通络液低剂量组(低剂量组)、心脑通络液高剂量组(高剂量组)、血脂康组(药物对照组),每组8只,建立腹主动脉粥样硬化家兔模型,造模成功后,连续3个月使用药物治疗,观察动脉粥样硬化家兔血管内皮病理组织学、超微结构变化。结果:心脑通络液可对动脉粥样硬化兔血管内膜的病理损伤起修复作用。结论:心脑通络液可修复动脉粥样硬化兔腹主动脉病理组织学、超微结构,并对动脉粥样硬化兔血管内膜的病理损伤有一定的修复作用。Objective： To observe the effects of Xinnao Tongluo liquid on the pathological histology and ultrastructure of vascular endothelium in rabbits with atherosclerosis,and to investigate the therapeutic effects of Xinnao Tongluo liquid in the treatment of atherosclerosis. Methods： A total of 40 New Zealand rabbits were randomly divided into five groups： sham- operation group（ blank group）,model group,low- dose and high- dose Xinnao Tongluo liquid groups,and Xuezhikang group（ drug control group）（ n = 8 for each）. They were treated to establish a model of abdominal aorta atherosclerosis. After the model was successfully established,the Xinnao Tongluo liquid groups and Xuezhikang group were given Xinnao Tongluo liquid and Xuezhikang,respectively; the model group was given saline; the sham- operation group was fed conventionally. The changes in pathological histology and ultrastructure of vascular endothelium in rabbits with atherosclerosis were observed. Results： Xinnao Tongluo liquid could repair the pathological lesion of tunica intima in rabbits with atherosclerosis. Conclusion： Xinnao Tongluo liquid can repair the pathological histology and ultrastructure of the abdominal aorta,as well as the pathological lesion of tunica intima,in rabbits with atherosclerosis.

关 键 词：动脉粥样硬化 兔 心脑通络液 病理组织学 超微结构 实验研究 

分 类 号：R285.5[医药卫生—中药学]