微波辐射法合成7-羟基-4-甲基香豆素  

Synthesis of 7-Hydroxyl-4-Methylcoumarin under Microwave Irradiation

作　　者：张博[1] 马飞[1] 白丽丽[1] 

机构地区：[1]海南医学院药学院,海南海口571199

出　　处：《广东化工》2015年第4期20-20,40,共2页Guangdong Chemical Industry

基　　金：国家大学生创新创业基金(201311810048)

摘　　要：以对甲苯磺酸作为催化剂,微波辐射间苯二酚和乙酰乙酸乙酯反应合成7-羟基-4-甲基香豆素。结果表明,在乙酸乙酯存在下,微波加热1 min（档位为中高火,560 W）,n（乙酰乙酸乙酯）∶n（间苯二酚）=1.3,对甲苯磺酸用量为间苯二酚物质的量的6.0%,产品收率达到65%~82%。该方法操作简单,反应时间短且收率高,环境友好。7-Hydroxyl-4-methylcoumarin was synthesized by the reaction of the resorcinol with the ethyl acetoacetate, and p-toluenesulfonic acidas a catalyst under microwave irradiation. when n（ethyl acetoacetate）∶n（resorcinol）=1.3 and the dosage of the p-toluenesulfonic acid was 6.0 % of the resorcinol in ethyl acetate, the reactions were completed in 1 min（high range, 560 W）, with 65 %~82% yields. The procedure has the advantages of short reaction time, easy work-up,moderate yield and environmental begin.

关 键 词：香豆素 合成 微波辐射 对甲苯磺酸 

分 类 号：TQ[化学工程]