泽芪汤对顽固性腹水肾素、血管紧张素、醛固酮的影响  

The Influence of Ze Qi Decoction on Refractory Ascites and Renin and Angiotensin and Aldosterone

作　　者：郭海军[1] 佟雪飞[1] 

机构地区：[1]邢台市人民医院,河北邢台054000

出　　处：《河南中医》2015年第2期295-297,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察泽芪汤治疗顽固性腹水的疗效及对肾素、血管紧张素、醛固酮的影响。方法:将86例乙型肝炎肝硬化顽固性腹水患者随机分为治疗组56例和对照组30例。对照组给予保肝利尿、输注人血白蛋白等治疗,治疗组在对照组治疗的基础上加用泽芪汤治疗。观察治疗前后两组腹水消退情况及血浆肾素活性(PRA)、血管紧张素Ⅱ(AII)、醛固酮(ALD)的变化情况。结果:治疗后,治疗组血浆PRA、AII、ALD水平显著下降,与对照组比较,有明显统计学差异(P<0.05);两组临床疗效比较,治疗组有效率为73.2%,对照组有效率为53.3%,治疗组优于对照组(P<0.05)。结论:泽芪汤治疗肝硬化顽固性腹水,可显著促进顽固性腹水的消退,抑制肾素-血管紧张素-醛固酮系统(RAAS)活性,避免因利尿诱发RAAS过度激活。Objective： To observe the clinical curative effect of Ze Qi Decoction（ ZQD） in treating refractory ascites and its influence on rennin,angiotensin and aldosterone. Methods： 70 patients with hepatitis B hepatocirrhosis with intractable ascites were randomly divided into the treatment group and the control group,with 56 and 30 cases in each group respectively. The patients in the control group were given medicine for protecting liver to promote dieresis,and injection of serum albumin,while the ones in the treatment group were added ZQD on the basis treatment of the control group. Then the ascites extinctive condition,the changes of plasma PRA,AII and ALD in both groups were observed before and after the treatment. Results： After the treatment,the levels of plasma PRA,AII and ALD of the treatment group greatly decreased. The differences between the treatment group and the control group had statistical meaning（ P〈0. 05）. The total effective rate of the treatment group（ 73. 2%） was better than that（ 53. 3%）of the control group（ P〈0. 05）. Conclusion： ZQD can greatly promote the ascites extinctive condition on hepatocirrhosis with intractable ascites,inhibit the activity of PRA,AII and ALD system（ RAAS）,and avoid RAAS excessive activation caused by promoting dieresis.

关 键 词：泽芪汤 顽固性腹水 肾素 血管紧张素 醛固酮 

分 类 号：R259.425[医药卫生—中西医结合]