沙美特罗/丙酸氟替卡松联合百令胶囊治疗慢性阻塞性肺疾病的临床研究  

Salmeterol/fluticasone propionate combined with bailing capsule in the treatment of acute chronic obstructive pulmonary disease

作　　者：舒成喆 顾亮[2] 

机构地区：[1]上海市天山中医医院药剂科,上海200051 [2]浙江医院呼吸内科,杭州310013

出　　处：《中国临床药理学杂志》2015年第4期247-249,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省中医药科学研究基金资助项目(2013ZB016)

摘　　要：目的评价百令胶囊联合沙美特罗/丙酸氟替卡松(SM/FP)对比单用SM/FP治疗稳定期老年中度慢性阻塞性肺疾病(COPD)患者的临床疗效。方法将我院收治的老年COPD患者80例随机分为试验组(n=38)和对照组(n=42)。对照组单用SM/FP(50μg/100μg)治疗,试验组用百令胶囊3 g·d-1联合SM/FP治疗,2组均用药6个月。分别于治疗前后测定患者一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC及6 min步行距离测试(6MWT)。随访1年,观察患者急性发作情况。结果治疗6个月后,试验组患者的FEV1、FVC、FEV1/FVC及6MWT均较治疗前显著改善,差异有统计学意义(P<0.05)。随访1年后,试验组的急性发作次数为(2.8±1.9)次,明显低于对照组(4.1±2.1)次(P<0.05);试验组的稳定期持续时间为(209.3±34.2)d,明显高于对照组(47.2±54.3)d(P<0.05)。结论百令胶囊联合沙美特罗/丙酸氟替卡松能更好地预防COPD急性发作,改善患者肺功能和生活质量。Objective To evaluate the clinical efficacy of salmeterol /fluticasone propionate combined with bailing capsule in the treatment of chronic obstructive pulmonary disease（ COPD）. Methods Eighty cases with COPD were recruited in this study from Dec 2011 to Feb 2013. The included subjects were randomized divided into experiment group（ n = 38） and control group（ n = 42）. Patients in experiment group were given salmeterol / fluticasone propionate（ 50 μg /100 μg） combined with bailing capsule 3 g·d^- 1,while patients in the control group were given salme-terol / fluticasone propionate only. After 6- month treatment,the data of forced expiratory volume in one second（ FEV1）,forced vital capacity（ FVC）,FEV1 / FVC and 6 minutes walking test（ 6MWT） were recorded and compared between two groups. Results The data of FEV1,FVC,FEV1 / FVC and 6MWT were all improved after 6- month treatment in the groups（ P〈0. 05）. The onset rate in the experiment group was much lower than that in the control group [（ 2. 8 ± 1. 9） vs（ 4. 1 ± 2. 1）,P〈0. 05],and the COPD stable period in the experiment group was much longer than that in the control group [（ 209. 3 ± 34. 2）vs（ 47. 2 ± 54. 3）,P〈0. 05]. Conclusion The salmeterol / fluticasone propionate combined with bailing capsule can significantly prevent theCOPD patients from acute seizures,and the quality of life would be improved.

关 键 词：稳定期 慢性阻塞性肺疾病 沙美特罗/丙酸氟替卡松 百令胶囊 

分 类 号：R563[医药卫生—呼吸系统] R974.2[医药卫生—内科学]