阿托品对靶控输注诱导气管插管时脑电双频指数的影响  

Influence of atropine on the bispectral index response to endotracheal intubation induced by target controlled infusion

作　　者：程李健[1] 徐慧[1] 殷萍[1] 兰允平[1] 

机构地区：[1]浙江省衢州市人民医院麻醉科,浙江衢州324000

出　　处：《中国临床药理学杂志》2015年第4期264-266,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省衢州市科技局基金资助项目(2013073)

摘　　要：目的评价阿托品对靶控输注诱导气管插管时脑电双频指数(BIS)的影响。方法入选行择期腹腔镜胆囊切除手术患者70例,随机分为阿托品组和对照组,每组各35例。2组均用靶控输注法诱导,首先微泵输入丙泊酚与瑞芬太尼,4 min后,阿托品组患者静脉推注阿托品10μg·kg-1,对照组推注同等容量0.9%Na Cl,10 min后开始气管插管。记录诱导开始15 min内患者的平均动脉压(MAP)、心率(HR)和BIS。结果与插管前即刻的BIS值比较,插管后1 min2组的BIS值均明显增高(P<0.05)。插管后3,5 min,阿托品组BIS值较对照组明显增高[(52.83±4.00)vs(48.92±3.00),(48.81±4.00)vs(46.53±4.20)](P<0.05)。插管前2 min、插管前即刻和插管后3,5 min,2组患者的MAP和HR比较差异有统计学意义(P<0.05)。结论靶控输注诱导气管插管时用阿托品会引起BIS值升高。Objective To evaluate the influence of atropine on the bispectral index（ BIS） response to endotracheal intubation induced by target controlled infusion. Methods Seventy patients who were scheduled laparoscopic cholecystectomy were randomly divided into atropine group and control group,35 patients in each group. First,patients in two groups were induced by target controlled infusion,with propofol and remifentanil pumped. After four minutes,patients received either atropine（ 10 μg·kg- 1） or an equal volume of 0. 9% Na Cl injection. Tracheal intubation was performed 10 minutes after anesthetic induction.The data of BIS,mean arterial pressure（ MAP） and heart rate（ HR） were recorded during the 15- minute anesthesia induction. Results BIS values of the two groups 1 minute after intubation were significantly increased compared with those before intubation（ P〈0. 05）. Compared with control group,BIS values in atropine group were significantly higher three and five minutes after intubation [（ 52. 83 ± 4. 00） vs（ 48. 8 ± 4. 00）,（ 48. 9 ± 4. 00） vs（ 46. 53 ± 4. 20） ]（ P〈0. 05）. There were statistical differences between two groups in the data of MAP and HR 2 minutes before intubation,immediately before intubation,as well as three and five minutes after intubation,respectively. Conclusion Atropine can increase BIS value response to endotracheal intubation induced by target controlled infusion.

关 键 词：阿托品 脑电双频指数 气管插管 靶控输注 丙泊酚 

分 类 号：R971.2[医药卫生—药品] R264.2[医药卫生—药学]