纳洛酮拮抗舒芬太尼的兔定量药物脑电图β_1频段功率百分比效应  

Naloxone's inhibition on the effects of sulfentanil on percentage of β_1-band power of quantitative pharmaco-electroencephalography in rabbits

作　　者：张丹[1] 李贺[2] 王孝庆[2] 徐佳雯[2] 于亚梅[2] 戴体俊[3] 

机构地区：[1]徐州医学院研究生院,江苏徐州221002 [2]徐州医学院麻醉学院,江苏徐州221002 [3]徐州医学院麻醉药理学教研室,江苏徐州221002

出　　处：《中国临床药理学杂志》2015年第4期286-288,291,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30872432;30471657;39970715);江苏省社会发展科技计划基金资助项目(BS 200054);徐州医学院药学院研究生科研创新计划基金资助项目(2010YKYCX011)

摘　　要：目的探讨舒芬太尼对兔定量药物脑电图(QPEEG)β1频段的影响及其与阿片受体的关系。方法 36只成年家兔随机分为6组(n=6):空白组(0.9%Na Cl 1 m L·kg-1),低、中、高3个剂量舒芬太尼组(1.5,3,6μg·kg-1),纳洛酮组(400μg·kg-1)和联合用药组(纳洛酮400μg·kg-1+舒芬太尼3μg·kg-1)。采集给药前30 s及给药后1,3,5,10,20,25 min脑电图数据,分析QPEEG样本。结果与给药前相比,中、高剂量舒芬太尼组的β1频段功率百分比明显减少(P<0.05),且与舒芬太尼剂量呈负相关(P<0.05)。纳洛酮组与给药前相比,β1频段功率百分比无明显变化(P>0.05)。结论舒芬太尼以剂量依赖方式减少兔QPEEGβ1频段功率百分比,且此作用由阿片受体介导。Objective To explore the effects of sulfentanil on the percentage of β1- band power of quantitative pharmaco- electroencephalography（ QPEEG） in rabbits, and its relationship with opioid receptor. Methods Thirty- six healthy rabbits were divided randomly into six groups（ n = 6） ： normal group（ 0. 9% Na Cl 1 m L·kg- 1）,low,medium,high doses sulfentanil groups（ 1. 5,3,6 μg · kg^- 1naloxone group（ 400 μg·kg- 1） and naloxone and sulfentanil group（ naloxone 400μg·kg- 1and sulfentanil 3 μg · kg^- 1 The percentage of each band power was respectively noted down 30 s before administration and 1,3,5,10,20,25 min after administration. Results Compared with the baseline,the percentage of β1- band power was decreased in the groups of medium,high doses sulfentanil（ P〈0. 05）,which had a negative correlation with sulfentanil dose（ P〈0. 05）. There was no obvious change in the percentage of β1- band power in the group of naloxone compared with the baseline（ P〉0. 05）. Conclusion Sulfentanil decreases the percentage of β1- band power in a dose- dependent manner,and this effect is mediated by the opioid receptor.

关 键 词：舒芬太尼 纳洛酮 阿片受体 镇痛程度 定量药物脑电图 β1频段 

分 类 号：R971.2[医药卫生—药品] R965.1[医药卫生—药学]