响应面法优化4-羟基苯并唑-2-硫酮的合成  

Synthesis of 4-Hydroxy-benzo[d]oxazole-2(3H)-thione by Response Surface Methodology

作　　者：高翔[1] 赵农[1] 吴峥[1] 韦芳可 袁福林 龙盛京[1] 

机构地区：[1]广西医科大学药学院,广西南宁530021

出　　处：《化学试剂》2015年第3期217-220,224,共5页Chemical Reagents

摘　　要：采用单因素法和响应面法相结合,对合成标题化合物的工艺条件进行优化。在单因素的实验基础上,再采用响应面法对原料配比、反应时间和反应后处理p H这3个关键因素进行优化分析,得到了标题化合物收率的计算模型,并得到优化条件:原料物质的量配比为n(2-氨基间苯二酚盐酸盐)∶n(乙基黄原酸钾)=1∶1.42,反应时间为4 h,反应后处理调节至p H 5,此条件下合成产率为65.28%。该合成工艺条件产率较高且稳定,可作为合成标题化合物的实验依据。The optimized synthesis conditions of 4-hydeoxy-benzo[d]oxazole-2（ 3H）-thione with single factor optimization and response surface methodology（ RSM）. Based on the single factor experiments,using RSM to analysis the key factors： substrate ratio,reaction time and pH of after reaction to build mathematic yield model of 4-hydeoxy-benzo[d]oxazole-2（ 3H）-thione and optimized conditions： substrates mole ratio of n（ 2-amimoresorcinol hydrochloride） ∶ n（ potassium ethyl xanthate） = 1 ∶ 1. 42,reaction time 4 h and acidified to pH 5 after reaction. In the conditions,4-hydeoxy-benzo[d]oxazole-2（ 3H）-thione obtained high yield,up to 65. 28% and the conditions are stable. So this paper provides an experimental technology to synthesis 4-hydeoxy-benzo[d]oxazole-2（ 3H）-thione.

关 键 词：响应面分析法 4-羟基苯并噁唑-2-硫酮 合成工艺 

分 类 号：TQ031.2[化学工程]