中药联合TP方案治疗晚期卵巢癌的系统评价  

Systematic Review of Traditional Chinese Medicine Combined with TP Regimen in Treatment of Advanced Ovarian Cancer

作　　者：赵迪[1] 邓婕[2] 朱燕婷[2] 史道华[1] 

机构地区：[1]福建中医药大学药学院,福州350122 [2]福建省妇幼保健院药剂科,福州350001

出　　处：《海峡药学》2015年第1期71-73,共3页Strait Pharmaceutical Journal

摘　　要：目的系统评价中药联合TP方案(紫杉醇+顺铂或紫杉醇+卡铂)治疗晚期卵巢癌的疗效及不良反应。方法检索CNKI、VIP、CBM和万方数据库,时限不限,检索策略为中药联合TP方案治疗晚期卵巢癌的随机对照试验(RCTs),运用Rev Man 5.1软件进行Meta分析。结果纳入的10篇RCTs显示,中药可增强TP方案治疗晚期卵巢癌的有效率〔OR=0.69,95%CI=(0.51,0.94),P=0.02〕,改善患者的生存质量〔OR=0.32,95%CI=(0.14,0.70),P=0.005〕,以及降低化疗药所引起的胃肠道反应〔OR=2.47,95%CI=(1.24,4.90),P=0.01〕。结论中药可增强铂类化疗药常规治疗的有效率,减轻毒副作用。OBJECTIVE To evaluate efficacy and side effects of traditional Chinese medicine combined with TP regimen on advanced ovarian cancer patients. METHODS Data of randomized controlled trials（ RCTs） of traditional Chinese medicine combined with TP regimen were retrieved from CNKI,VIP,CBM and WANFANG database. Statistics analysis was performed by Revman 5. 1 software. RESULTS 10 RCTs were included in the study. Meta-analysis showed that the efficacy was improved〔OR = 0. 69,95% CI =（ 0. 51,0. 94）,P = 0. 02 〕,the quality of life was lengthened〔OR = 0. 32,95% CI =（ 0. 14,0. 70）,P = 0. 005 〕,and the gastrointestinal reactions were decreased〔OR = 2. 47,95% CI =（ 1. 24,4. 90）,P = 0. 01 〕in TP regimen combined with traditional Chinese medicine on advanced ovarian cancer patients. CONCLUSION Traditional Chinese medicine has advantages of enhancing efficacy and reducing toxicity in platinum therapy on advanced ovarian cancer patients.

关 键 词：中药 晚期卵巢癌 META分析 

分 类 号：R969.4[医药卫生—药理学]