ELF脉冲电磁场对脑组织钙离子迁移量的影响  

Effect of ELF pulsed electromagnetic field on calcium ion migration in brain tissue

作　　者：周永军[1] 张辉[1] 牛中奇[2] 

机构地区：[1]咸阳师范学院物理与电子工程学院,陕西咸阳712000 [2]西安电子科技大学电子工程学院,西安710071

出　　处：《北京生物医学工程》2015年第1期49-53,共5页Beijing Biomedical Engineering

基　　金：国家自然科学基金(30470429);咸阳师范学院科研基金(11XSYK102)资助

摘　　要：目的研究极低频(extremely low frequency,ELF)脉冲电磁场对脑组织钙离子迁移量的影响。方法以鸡脑组织为生物学实验对象,以同位素示踪法为标记方法,用液体闪烁计数器为检测仪器,实验观察ELF脉冲电磁场对脑组织钙离子迁移量的影响。结果不同特征外加ELF脉冲电磁场对脑组织钙离子迁移量影响不同,如频率为16 Hz、场强为42.5 V/m的ELF脉冲电磁场可引起脑组织钙离子迁移量显著变化。频率为16 Hz、场强为62.2 V/m与频率为31 Hz、场强为42.5 V/m的ELF脉冲电磁场却未引起脑组织钙离子迁移量显著改变。结论只有频率和强度恰当组合的ELF电磁场才可引起脑组织钙离子迁移量显著升高,呈现出生物学窗效应。另一方面在既注重物理学分析又注重生物系统特性基础上,从膜通道内的带电粒子动力学方程入手分析讨论生物学窗效应产生机制。Objective To study on the effect of extremely low frequency （ELF） pulsed electromagnetic field on calcium ion migration in brain tissue. Methods Chick brain tissue as the biological subjects, isotope tracing as marking methods, and liquid scintillation counter as the detector measuring for radioactivity intensity, the effects of ELF pulsed electromagnetic field on calcium ion migration in brain tissue were studied through experiments in this paper. Results Calcium ion migration in brain tissue was different after exposure to external pulsed electromagnetic field with different properties. The external pulsed electromagnetic field with intensity as 42.5 V/m and frequency as 16 Hz caused a significant change of calcium ion migration in the brain tissue. While the one with intensity as 62.2 V/m and frequency as 16 Hz, and the one with intensity as 42.5 V/m and frequency as 31 Hz did not cause significant change of calcium ion migration. Conclusions Only the right combination of frequency and intensity of ELF electromagnetic field can cause a significant change of calcium ion migration in brain tissue, which shows the biological window effects. On the other hand, based on the emphasis on the physical analysis and characteristics of biological system, the mechanism of ELF pulsedelectromagnetic field imposed on the calcium ion migration in brain tissue is explained with the kinetic equation for charged particles in the membrane ion channels.

关 键 词：极低频脉冲电磁场 脑组织 钙迁移量 

分 类 号：R318.04[医药卫生—生物医学工程]