臭灵丹抗甲1型流感病毒FM1株感染小鼠的药效学研究  

Antiviral Activity of Laggera pterodonta Against Influenza A Virus Infection in Mice

作　　者：王玉涛[1,2] 李菁[2] 夏晓玲[3] 孙强明 于浩飞[3] 杨子峰[2] 潘锡平[2] 张荣平[3] 王新华[5] 

机构地区：[1]广州中医药大学热带医学研究所,广东广州510405 [2]广州医科大学附属第一医院,呼吸疾病国家重点实验室,广东广州510230 [3]昆明医科大学,云南昆明650500 [4]中国医学科学院医学生物学研究所,云南昆明650031 [5]广州医科大学,广东广州510182

出　　处：《广州中医药大学学报》2015年第2期282-284,289,385,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81460593);广州市教育系统创新学术团队项目(编号:13C07);广州市科技计划项目-科技惠民专项(编号:2014Y2-00031);广州市健康医疗协同创新重大专项(编号:201400000002);云南省应用基础研究重点项目(编号:2014FA031)

摘　　要：【目的】观察臭灵丹抑制甲1型流感病毒FM1株感染的体内药效。【方法】采用小鼠流感病毒性肺炎模型,通过检测小鼠体质量变化和肺指数、肺组织病理变化确认药物的体内抗病毒药效。【结果】病毒对照组的肺指数较正常对照组显著升高(P<0.001),表明该模型复制成功;臭灵丹高、中、低剂量组均未能有效缓解流感病毒感染小鼠的体质量下降(P>0.05);臭灵丹高、中、低剂量组可显著降低流感病毒感染小鼠的肺指数(P<0.05)。小鼠肺组织病理检查结果显示:臭灵丹低剂量组可以缓解肺组织病理性炎症。【结论】臭灵丹对甲1型流感病毒FM1株感染小鼠的病毒性肺炎具有一定的抑制作用。Objective To study the inhibitory effect of Laggera pterodonta（ DC.） Benth. against influenza A virus infection in mice. Methods Mice model of pneumonia was established after infection with influenza virus.The changes of body mass, lung index and lung pathology were observed to verify the in-vivo antiviral activity of Laggera pterodonta. Results The lung index of the virus control group was higher than that of the normal control group（P〈0.001）, indicating the successful establishment of influenza-virus-induced pneumonia model. High-,moderate-and low-dose Laggera pterodonta had no effect on counteracting the decrease of body mass of model mice（P〉0.05）, but had obvious effect on decreasing the lung index of the model mice（P〈0.05）. Moreover,low-dose Laggera pterodonta had an effect on relieving the pulmonary inflammation in the infected mice. Conclusion Laggera pterodonta exerts certain inhibitory effect on viral pneumonia mice induced by influenza A virus infection.

关 键 词：臭灵丹/药理学 流感/中药疗法 肺/病理学 疾病模型 动物 小鼠 

分 类 号：R285.5[医药卫生—中药学]